Valethamate bromide | CAS#90-22-2 | Antispasmodic agent

MedKoo Cat#: 463545 | Name: Valethamate bromide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Valethamate bromide is an antispasmodic agent used to shorten the duration of active labour.

Chemical Structure

Valethamate bromide

CAS#90-22-2

Theoretical Analysis

MedKoo Cat#: 463545

Name: Valethamate bromide

CAS#: 90-22-2

Chemical Formula: C19H32BrNO2

Exact Mass: 385.1616

Molecular Weight: 386.37

Elemental Analysis: C, 59.06; H, 8.35; Br, 20.68; N, 3.63; O, 8.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Valethamate bromide; Ediposin; Epidozin; Murel; Resitan;

IUPAC/Chemical Name

N,N-diethyl-N-methyl-2-((3-methyl-2-phenylpentanoyl)oxy)ethan-1-aminium bromide

InChi Key

CEJGGHKJHDHLAZ-UHFFFAOYSA-M

InChi Code

InChI=1S/C19H32NO2.BrH/c1-6-16(4)18(17-12-10-9-11-13-17)19(21)22-15-14-20(5,7-2)8-3;/h9-13,16,18H,6-8,14-15H2,1-5H3;1H/q+1;/p-1

SMILES Code

CCC(C(c1ccccc1)C(OCC[N+](CC)(CC)C)=O)C.[Br-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 386.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Köstü B, Kiran G, Ercan Ö, Bakacak M, Bostanci MS, Arikan D, Özdemir Ö. A randomised controlled study comparing valethamate bromide and placebo in shortening the duration of active labour. J Obstet Gynaecol. 2016;36(2):196-9. doi: 10.3109/01443615.2015.1041883. Epub 2015 Aug 7. PMID: 26291425. 2: Köstü B, Kiran G, Ercan Ö, Bakacak M, Bostanci MS, Arikan D, Özdemir Ö. A randomised controlled study comparing valethamate bromide and placebo in shortening the duration of active labour. J Obstet Gynaecol. 2015 Aug 7:1-4. Epub ahead of print. PMID: 26250872. 3: Stanton C, Nand DN, Koski A, Mirzabagi E, Brooke S, Grady B, Mullany LC. Accessibility and potency of uterotonic drugs purchased by simulated clients in four districts in India. BMC Pregnancy Childbirth. 2014 Nov 13;14:386. doi: 10.1186/s12884-014-0386-y. PMID: 25392131; PMCID: PMC4240854. 4: Sarbhjit K, S K B, Parmjit K, Surinder B. To compare the effect of camylofin dihydrochloride (anafortin) with combination of valethamate bromide (epidosin) and hyoscine butyl-N-bormide (buscopan) on cervical dilation. J Clin Diagn Res. 2013 Sep;7(9):1897-9. doi: 10.7860/JCDR/2013/6231.3345. Epub 2013 Jul 22. PMID: 24179892; PMCID: PMC3809631. 5: Rohwer AC, Khondowe O, Young T. Antispasmodics for labour. Cochrane Database Syst Rev. 2013 Jun 5;2013(6):CD009243. doi: 10.1002/14651858.CD009243.pub3. PMID: 23737030; PMCID: PMC6823273. 6: Rohwer AC, Khondowe O, Young T. Antispasmodics for labour. Cochrane Database Syst Rev. 2012 Aug 15;(8):CD009243. doi: 10.1002/14651858.CD009243.pub2. PMID: 22895986. 7: Babu TA, Sharmila V. Valethamate bromide: Conflicting evidence and continuing use. J Pharmacol Pharmacother. 2010 Jul;1(2):120. doi: 10.4103/0976-500X.72365. PMID: 21350626; PMCID: PMC3043334. 8: George N, Shiny PJ, Miriam J, Nancy CA, Dhanasekar KR, Peedicayil J. Inhibitory effect of anticholinergics on the contraction of isolated caprine urinary bladder detrusor muscle. Auton Autacoid Pharmacol. 2010 Jul;30(3):173-7. doi: 10.1111/j.1474-8673.2009.00447.x. Epub 2010 Jan 19. PMID: 20085574. 9: Gitanjali B. Valethamate bromide: Is there any proof of efficacy and safety for its use in labor? J Pharmacol Pharmacother. 2010 Jan;1(1):2-3. doi: 10.4103/0976-500X.64528. PMID: 21808583; PMCID: PMC3142753. 10: Yilmaz B, Kart C, Kelekci S, Gokturk U, Sut N, Tarlan N, Mollamahmutoglu L. Meperidine versus valethamate bromide in shortening the duration of active labor. Int J Gynaecol Obstet. 2009 Nov;107(2):126-9. doi: 10.1016/j.ijgo.2009.06.021. Epub 2009 Aug 6. PMID: 19664769. 11: Madhu C, Mahavarkar S, Bhave S. A randomised controlled study comparing Drotaverine hydrochloride and Valethamate bromide in the augmentation of labour. Arch Gynecol Obstet. 2010 Jul;282(1):11-5. doi: 10.1007/s00404-009-1188-8. Epub 2009 Jul 31. PMID: 19644697. 12: Sharma JB, Pundir P, Kumar A, Murthy NS. Drotaverine hydrochloride vs. valethamate bromide in acceleration of labor. Int J Gynaecol Obstet. 2001 Sep;74(3):255-60. doi: 10.1016/s0020-7292(01)00448-9. PMID: 11543749. 13: Bognar IT, Altes U, Beinhauer C, Kessler I, Fuder H. A muscarinic receptor different from the M1, M2, M3 and M4 subtypes mediates the contraction of the rabbit iris sphincter. Naunyn Schmiedebergs Arch Pharmacol. 1992 Jun;345(6):611-8. doi: 10.1007/BF00164573. PMID: 1635586. 14: Kuruvila S, Jasper P, Peedicayil A, Mathai M. A randomized controlled trial of valethamate bromide in acceleration of labor. Int J Gynaecol Obstet. 1992 Jun;38(2):93-6. doi: 10.1016/0020-7292(92)90042-h. PMID: 1356851. 15: Finkbeiner AE, Bissada NK, Welch LT. Uropharmacology: part VI. Parasympathetic depressants. Urology. 1977 Nov;10(5):503-10. doi: 10.1016/0090-4295(77)90149-2. PMID: 21482. 16: KIGER RG. Observations on the symptomatic treatment of porphyria with valethamate bromide. South Med J. 1962 Feb;55:154-5. doi: 10.1097/00007611-196202000-00012. PMID: 14455867. 17: NEW AND NONOFFICIAL Drugs: valethamate bromide. J Am Med Assoc. 1959 Jul 11;170(11):1316. PMID: 13664527. 18: WILKE H. Uber Epidosinanwendung im Kindesalter [Epidosin use in children]. Medizinische. 1958 May 24;3(21):890. German. PMID: 13551739. 19: SCHMIDT W. Die Wirkung eines neuen Spasmolytikums; Epidosin, in der Geburtshilfe [Effects of a new spasmolytic, epidosin, in obstretrics]. Medizinische. 1957 Jun 8;(23):870-1. German. PMID: 13440464. 20: BECK HU. Erfahrungen mit dem Spasmolyticum Epidosin in der Geburtshilfe [Experiences with muscle relaxant epidosin in obstetrics]. Med Klin. 1956 Aug 17;51(33):1372-4. German. PMID: 13358525.