MedKoo Cat#: 463520 | Name: JWX-A0108

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model.

Chemical Structure

JWX-A0108
JWX-A0108
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463520

Name: JWX-A0108

CAS#: unknown

Chemical Formula: C19H14ClFN4OS

Exact Mass: 400.0561

Molecular Weight: 400.86

Elemental Analysis: C, 56.93; H, 3.52; Cl, 8.84; F, 4.74; N, 13.98; O, 3.99; S, 8.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JWX-A0108; JWXA0108; JWX A0108;
IUPAC/Chemical Name
6-(2-chloro-6-methylphenyl)-2-((3-fluoro-4-methylphenyl)amino)thiazolo[4,5-d]pyrimidin-7(6H)-one
InChi Key
HLGMORDKLMTTGN-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H14ClFN4OS/c1-10-6-7-12(8-14(10)21)23-19-24-17-16(27-19)18(26)25(9-22-17)15-11(2)4-3-5-13(15)20/h3-9H,1-2H3,(H,23,24)
SMILES Code
CC1=CC=C(NC2=NC(N=CN(C3=C(Cl)C=CC=C3C)C4=O)=C4S2)C=C1F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 400.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sun LL, Yang TY, Wei NN, Lu W, Jiao WX, Zhou QQ, Miao YZ, Gao Q, Wang XT, Sun Q, Wang K. Pharmacological characterization of JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model. Acta Pharmacol Sin. 2019 Jun;40(6):737-745. doi: 10.1038/s41401-018-0163-y. Epub 2018 Oct 17. PMID: 30333556; PMCID: PMC6786413.