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MedKoo Cat#: 575204 | Name: AZD-3199 dihydrobromide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZD-3199 dihydrobromide is a β2 adrenergic receptor agonist potentially for the treatment of asthma and chronic obstructive.

Chemical Structure

AZD-3199 dihydrobromide
AZD-3199 dihydrobromide
CAS#925244-40-2

Theoretical Analysis

MedKoo Cat#: 575204

Name: AZD-3199 dihydrobromide

CAS#: 925244-40-2

Chemical Formula: C32H44Br2N4O4S

Exact Mass: 738.1450

Molecular Weight: 740.60

Elemental Analysis: C, 51.90; H, 5.99; Br, 21.58; N, 7.57; O, 8.64; S, 4.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
AZD-3199 dihydrobromide; AZD3199 dihydrobromide; AZD 3199 dihydrobromide
IUPAC/Chemical Name
N-(2-(Diethylamino)ethyl)-N-(2-((2-(4-hydroxy-2-oxo-2,3-dihydro-1,3-benzothiazol-7-yl)ethyl)amino)ethyl)-3-(2-(1-naphthyl)ethoxy)propanamide dihydrobromide
InChi Key
WORMGNDAXQYVAV-UHFFFAOYSA-N
InChi Code
InChI=1S/C32H42N4O4S.2BrH/c1-3-35(4-2)20-21-36(19-18-33-17-14-26-12-13-28(37)30-31(26)41-32(39)34-30)29(38)16-23-40-22-15-25-10-7-9-24-8-5-6-11-27(24)25;;/h5-13,33,37H,3-4,14-23H2,1-2H3,(H,34,39);2*1H
SMILES Code
Br.Br.CCN(CC)CCN(CCNCCc1ccc(O)c2NC(=O)Sc12)C(=O)CCOCCc3cccc4ccccc34
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 740.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bjermer L, Kuna P, Jorup C, Bengtsson T, Rosenborg J. Clinical pharmacokinetics of AZD3199, an inhaled ultra-long-acting β2-adrenoreceptor agonist (uLABA). Drug Des Devel Ther. 2015 Feb 5;9:753-62. doi: 10.2147/DDDT.S66049. PubMed PMID: 25709399; PubMed Central PMCID: PMC4330041. 2: Bjermer L, Rosenborg J, Bengtsson T, Lötvall J. Comparison of the bronchodilator and systemic effects of AZD3199, an inhaled ultra-long-acting β₂-adrenoceptor agonist, with formoterol in patients with asthma. Ther Adv Respir Dis. 2013 Oct;7(5):264-71. doi: 10.1177/1753465813497527. PubMed PMID: 23907810. 3: Kuna P, Ivanov Y, Trofimov VI, Saito T, Beckman O, Bengtsson T, Jorup C, Maltais F. Efficacy and safety of AZD3199 vs formoterol in COPD: a randomized, double-blind study. Respir Res. 2013 Jun 3;14:64. doi: 10.1186/1465-9921-14-64. PubMed PMID: 23731768; PubMed Central PMCID: PMC3691744. 4: Norman P. Which of three structures is AZD-3199? WO-2008104790, WO-2008096112 and WO-2008096119. Expert Opin Ther Pat. 2009 Aug;19(8):1157-63. doi: 10.1517/13543770902815527. PubMed PMID: 19563269.