Synonym
Cericlamine; UNII-VES82D23IB
IUPAC/Chemical Name
(+-)-3-(3,4-Dichlorophenyl)-2-(dimethylamino)-2-methyl-1-propanol.
InChi Key
FWYRGHMKHZXXQX-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H17Cl2NO/c1-12(8-16,15(2)3)7-9-4-5-10(13)11(14)6-9/h4-6,16H,7-8H2,1-3H3
SMILES Code
OCC(C)(N(C)C)CC1=CC=C(Cl)C(Cl)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
262.17
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Prechter A, Gröger H, Heinrich MR. Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates. Org Biomol Chem. 2012 May 7;10(17):3384-7. doi: 10.1039/c2ob25247c. Epub 2012 Mar 22. PMID: 22441297.
2: Jolas T, Haj-Dahmane S, Kidd EJ, Langlois X, Lanfumey L, Fattaccini CM, Vantalon V, Laporte AM, Adrien J, Gozlan H, et al. Central pre- and postsynaptic 5-HT1A receptors in rats treated chronically with a novel antidepressant, cericlamine. J Pharmacol Exp Ther. 1994 Mar;268(3):1432-43. PMID: 8138956.
3: Maudhuit C, Jolas T, Lainey E, Hamon M, Adrien J. Effects of acute and chronic treatment with amoxapine and cericlamine on the sleep-wakefulness cycle in the rat. Neuropharmacology. 1994 Aug;33(8):1017-25. doi: 10.1016/0028-3908(94)90161-9. PMID: 7845548.
4: Svestka J. Antidepresiva III., IV. a V. generace [Antidepressives of the 3rd, 4th and 5th generation]. Cesk Psychiatr. 1994 Feb;90(1):3-19. Czech. PMID: 8174184.
5: Maudhuit C, Jolas T, Chastanet M, Hamon M, Adrien J. Reduced inhibitory potency of serotonin reuptake blockers on central serotoninergic neurons in rats selectively deprived of rapid eye movement sleep. Biol Psychiatry. 1996 Nov 15;40(10):1000-7. doi: 10.1016/0006-3223(95)00583-8. PMID: 8915559.
6: Wettstein JG, Gauthier B. Discriminative stimulus effects of alprazolam and diazepam: generalization to benzodiazepines, antidepressants and buspirone. Behav Pharmacol. 1992 Jun;3(3):229-237. PMID: 11224120.
7: Gouret CJ, Porsolt R, Wettstein JG, Puech A, Soulard C, Pascaud X, Junien JL. Biochemical and pharmacological evaluation of the novel antidepressant and serotonin uptake inhibitor 2-(3,4-Dichlorobenzyl)-2-dimethylamino-1-propanol hydrochloride. Arzneimittelforschung. 1990 Jun;40(6):633-40. PMID: 2168703.
