JHU 37152 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs. It selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. JHU 37152 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons. It is brain penetrant in mice, rats and non-human primates.
MedKoo Cat#: 463510
Name: JHU 37152
CAS#: 2369979-67-7
Chemical Formula: C19H20ClFN4
Exact Mass: 358.1361
Molecular Weight: 358.85
Elemental Analysis: C, 63.60; H, 5.62; Cl, 9.88; F, 5.29; N, 15.61
The following data is based on the product molecular weight 358.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
