MedKoo Cat#: 575196 | Name: AZD-2207
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZD-2207 is a cannabinoid receptor CB1 antagonist and highly lipophilic compound for the treatment of type 2 diabetes mellitus and obesity.

Chemical Structure

AZD-2207
AZD-2207
CAS#866598-45-0

Theoretical Analysis

MedKoo Cat#: 575196

Name: AZD-2207

CAS#: 866598-45-0

Chemical Formula: C25H25Cl2F3N4O4S

Exact Mass: 604.0926

Molecular Weight: 605.45

Elemental Analysis: C, 49.59; H, 4.16; Cl, 11.71; F, 9.41; N, 9.25; O, 10.57; S, 5.30

Price and Availability

Size Price Availability Quantity
1mg USD 150.00 Ready to Ship
5mg USD 250.00 Ready to Ship
10mg USD 450.00 Ready to Ship
25mg USD 750.00 Ready to Ship
50mg USD 1,350.00 Ready to Ship
100mg USD 2,350.00 Ready to Ship
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Related CAS #
No Data
Synonym
AZD-2207; AZD2207; AZD 2207
IUPAC/Chemical Name
1-Propanesulfonic acid, 3,3,3-trifluoro-, 4-(2-(2,4-dichlorophenyl)-5-methyl-4-((1-piperidinylamino)carbonyl)-1H-imidazol-1-yl)phenyl ester
InChi Key
NHIXRYPUVCFFAF-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H25Cl2F3N4O4S/c1-16-22(24(35)32-33-12-3-2-4-13-33)31-23(20-10-5-17(26)15-21(20)27)34(16)18-6-8-19(9-7-18)38-39(36,37)14-11-25(28,29)30/h5-10,15H,2-4,11-14H2,1H3,(H,32,35)
SMILES Code
Cc1c(nc(c2ccc(Cl)cc2Cl)n1c3ccc(OS(=O)(=O)CCC(F)(F)F)cc3)C(=O)NN4CCCCC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
AZD-2207 is a cannabinoid receptor CB1 antagonist.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 605.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1. Tannergren C, Karlsson E, Sigfridsson K, Lindfors L, Ku A, Polentarutti B, Carlert S. Biopharmaceutic Profiling of Salts to Improve Absorption of Poorly Soluble Basic Drugs. J Pharm Sci. 2016 Nov;105(11):3314-3323. doi: 10.1016/j.xphs.2016.07.016. Epub 2016 Sep 13. PMID: 27637320. 2. Kourentas A, Vertzoni M, Barmpatsalou V, Augustijns P, Beato S, Butler J, Holm R, Ouwerkerk N, Rosenberg J, Tajiri T, Tannergren C, Symillides M, Reppas C. The BioGIT System: a Valuable In Vitro Tool to Assess the Impact of Dose and Formulation on Early Exposure to Low Solubility Drugs After Oral Administration. AAPS J. 2018 May 24;20(4):71. doi: 10.1208/s12248-018-0231-8. PMID: 29797293.