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MedKoo Cat#: 575194 | Name: Posizolid phosphate ester

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Posizolid phosphate ester is an oxazolidinone antibiotic.

Chemical Structure

Posizolid phosphate ester
Posizolid phosphate ester
CAS#252260-06-3

Theoretical Analysis

MedKoo Cat#: 575194

Name: Posizolid phosphate ester

CAS#: 252260-06-3

Chemical Formula: C21H22F2N3O10P

Exact Mass: 545.1011

Molecular Weight: 545.39

Elemental Analysis: C, 46.25; H, 4.07; F, 6.97; N, 7.70; O, 29.34; P, 5.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
AZD 2563DSP; Posizolid phosphate ester; Posizolid phosphate (ester)
IUPAC/Chemical Name
(S)-3-(4-(2,6-difluoro-4-((R)-5-((isoxazol-3-yloxy)methyl)-2-oxooxazolidin-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-hydroxy-3-oxopropyl dihydrogen phosphate
InChi Key
VZZBHEVJWKSWBN-PBHICJAKSA-N
InChi Code
InChI=1S/C21H22F2N3O10P/c22-15-7-13(26-9-14(36-21(26)29)10-33-18-3-6-34-24-18)8-16(23)19(15)12-1-4-25(5-2-12)20(28)17(27)11-35-37(30,31)32/h1,3,6-8,14,17,27H,2,4-5,9-11H2,(H2,30,31,32)/t14-,17+/m1/s1
SMILES Code
O[C@@H](COP(=O)(O)O)C(=O)N1CCC(=CC1)c2c(F)cc(cc2F)N3C[C@H](COc4ccon4)OC3=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 545.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jadhavar PS, Vaja MD, Dhameliya TM, Chakraborti AK. Oxazolidinones as Anti-tubercular Agents: Discovery, Development and Future Perspectives. Curr Med Chem. 2015;22(38):4379-97. PubMed PMID: 26549430. 2: Kumar D, Negi B, Rawat DS. The anti-tuberculosis agents under development and the challenges ahead. Future Med Chem. 2015 Oct;7(15):1981-2003. doi: 10.4155/fmc.15.128. Epub 2015 Oct 27. PubMed PMID: 26505682. 3: Tasneen R, Betoudji F, Tyagi S, Li SY, Williams K, Converse PJ, Dartois V, Yang T, Mendel CM, Mdluli KE, Nuermberger EL. Contribution of Oxazolidinones to the Efficacy of Novel Regimens Containing Bedaquiline and Pretomanid in a Mouse Model of Tuberculosis. Antimicrob Agents Chemother. 2015 Oct 26;60(1):270-7. doi: 10.1128/AAC.01691-15. PubMed PMID: 26503656.