IUPAC/Chemical Name
2,4-Dodecadienamide, N-(2-hydroxy-1-(((10-hydroxy-5-methyl-2,7-dioxo-1,6-diazabicyclododec-3-en-8-yl)amino)carbonyl)propyl)-11-methyl-, (5S-(3E,5R*,8R*(1R*(2E,4E),2S*),10R*))-
InChi Key
WXNCPYQOZWHGKA-PKIDYETQSA-N
InChi Code
InChI=1S/C40H68N4O6/c1-30(2)21-17-13-9-8-12-16-20-24-36(47)42-38(32(4)45)40(50)43-44-28-27-34(46)29-35(39(49)41-31(3)25-26-37(44)48)33-22-18-14-10-6-5-7-11-15-19-23-33/h12,16,20,24-26,30-35,38,45-46H,5-11,13-15,17-19,21-23,27-29H2,1-4H3,(H,41,49)(H,42,47)(H,43,50)/b16-12+,24-20+,26-25+/t31-,32+,34+,35-,38-/m0/s1
SMILES Code
CC(C)CCCCC/C=C/C=C/C(N[C@H](C(NN1C(/C=C/[C@H](C)NC([C@H](C2CCCCCCCCCCC2)C[C@H](O)CC1)=O)=O)=O)[C@H](O)C)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
701.01
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Stein ML, Beck P, Kaiser M, Dudler R, Becker CF, Groll M. One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18367-71. doi: 10.1073/pnas.1211423109. Epub 2012 Oct 22. PMID: 23091006; PMCID: PMC3494908.
3: Terui Y, Nishikawa J, Hinoo H, Kato T, Shoji J. Structures of cepafungins I, II and III. J Antibiot (Tokyo). 1990 Jul;43(7):788-95. doi: 10.7164/antibiotics.43.788. PMID: 2387773.
4: Shoji J, Hinoo H, Kato T, Hattori T, Hirooka K, Tawara K, Shiratori O, Terui Y. Isolation of cepafungins I, II and III from Pseudomonas species. J Antibiot (Tokyo). 1990 Jul;43(7):783-7. doi: 10.7164/antibiotics.43.783. PMID: 2387772.
