Forigerimod | CAS# 497156-60-2 | synthetic peptide

MedKoo Cat#: 412571 | Name: Forigerimod

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Forigerimod is a synthetic peptide, sequence 131-151 of the U1-70K protein phosphorylated at Ser140, which is recognized by lupus CD4 T cells for the treatment of patients with systemic lupus erythematosus.

Chemical Structure

Forigerimod

CAS#497156-60-2

Theoretical Analysis

MedKoo Cat#: 412571

Name: Forigerimod

CAS#: 497156-60-2

Chemical Formula: C117H181N34O32PS

Exact Mass: 2637.3039

Molecular Weight: 2638.97

Elemental Analysis: C, 53.25; H, 6.91; N, 18.05; O, 19.40; P, 1.17; S, 1.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Forigerimod; CEP33457; CEP-33457; CEP 33457

IUPAC/Chemical Name

L-Tyrosine, L-arginyl-L-isoleucyl-L-histidyl-L-methionyl-L-valyl-L-tyrosyl-L-seryl-L-lysyl-L- arginyl-O-phosphono-L-serylglycyl-L-lysyl-L-prolyl-L-arginylglycyl-L-tyrosyl-L-alanyl-L- phenylalanyl-L-isoleucyl-L-alpha-glutamyl-

InChi Key

CPIHRNOIKBVCBM-GGVFYUGVSA-N

InChi Code

InChI=1S/C117H181N34O32PS/c1-9-64(5)94(149-97(161)75(120)52-67-22-12-11-13-23-67)111(175)142-80(42-43-92(158)159)102(166)138-78(27-19-48-129-116(123)124)101(165)146-87(60-152)99(163)132-58-90(156)135-82(25-15-17-46-119)113(177)151-50-21-29-89(151)109(173)141-76(26-18-47-128-115(121)122)98(162)131-59-91(157)136-83(53-68-30-36-72(154)37-31-68)105(169)134-66(7)96(160)137-79(28-20-49-130-117(125)126)103(167)150-95(65(6)10-2)112(176)144-85(56-71-57-127-62-133-71)107(171)140-81(44-51-185-8)104(168)148-93(63(3)4)110(174)143-84(54-69-32-38-73(155)39-33-69)106(170)147-88(61-153)108(172)139-77(24-14-16-45-118)100(164)145-86(114(178)179)55-70-34-40-74(41-35-70)183-184(180,181)182/h11-13,22-23,30-41,57,62-66,75-89,93-95,152-155H,9-10,14-21,24-29,42-56,58-61,118-120H2,1-8H3,(H,127,133)(H,131,162)(H,132,163)(H,134,169)(H,135,156)(H,136,157)(H,137,160)(H,138,166)(H,139,172)(H,140,171)(H,141,173)(H,142,175)(H,143,174)(H,144,176)(H,145,164)(H,146,165)(H,147,170)(H,148,168)(H,149,161)(H,150,167)(H,158,159)(H,178,179)(H4,121,122,128)(H4,123,124,129)(H4,125,126,130)(H2,180,181,182)/t64-,65-,66-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,93-,94-,95-/m0/s1

SMILES Code

O=C(O)[C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](C(C)C)NC([C@H](CCSC)NC([C@H](CC3=CNC=N3)NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CC4=CC=C(O)C=C4)NC(CNC([C@H](CCCNC(N)=N)NC([C@H]5N(C([C@H](CCCCN)NC(CNC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC6=CC=CC=C6)N)=O)=O)=O)=O)=O)=O)=O)CCC5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 2,638.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Petrillo DE, Mowrey DR, Allwein SP, Bakale RP. A general preparation of protected phosphoamino acids. Org Lett. 2012 Mar 2;14(5):1206-9. doi: 10.1021/ol203332j. Epub 2012 Feb 22. PMID: 22356680.

View History

Forbisen

MedKoo CAT#: 145825

CAS#: 517-83-9