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MedKoo Cat#: 463491 | Name: MK-5204

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MK-5204 is a novel orally active β-1,3-glucan synthesis inhibitor.

Chemical Structure

MK-5204
MK-5204
CAS#1207751-75-4

Theoretical Analysis

MedKoo Cat#: 463491

Name: MK-5204

CAS#: 1207751-75-4

Chemical Formula: C40H65N5O5

Exact Mass: 695.4986

Molecular Weight: 695.99

Elemental Analysis: C, 69.03; H, 9.41; N, 10.06; O, 11.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MK-5204; MK5204; MK 5204; BM178545; BM 178545; BM-178545;
IUPAC/Chemical Name
(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-2-((R)-2-amino-2,3,3-trimethylbutoxy)-3-(5-carbamoyl-1H-1,2,4-triazol-1-yl)-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid
InChi Key
SBOWFTBCBBACFO-MBSXJOJQSA-N
InChi Code
InChI=1S/C40H65N5O5/c1-23(2)24(3)35(7)16-17-37(9)25-12-13-28-36(8)19-49-21-40(28,26(25)14-15-38(37,10)29(35)33(47)48)18-27(45-32(31(41)46)43-22-44-45)30(36)50-20-39(11,42)34(4,5)6/h14,22-25,27-30H,12-13,15-21,42H2,1-11H3,(H2,41,46)(H,47,48)/t24-,25+,27-,28+,29-,30+,35-,36-,37-,38+,39+,40+/m1/s1
SMILES Code
O=C([C@H]1[C@]2(C)CC=C3[C@]4(C[C@@H](N5N=CN=C5C(N)=O)[C@@H]6OC[C@](C)(N)C(C)(C)C)COC[C@]6(C)[C@]4([H])CC[C@]3([H])[C@@]2(C)CC[C@]1(C)[C@@H](C(C)C)C)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 695.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Apgar JM, Wilkening RR, Parker DL Jr, Meng D, Wildonger KJ, Sperbeck D, Greenlee ML, Balkovec JM, Flattery AM, Abruzzo GK, Galgoci AM, Giacobbe RA, Gill CJ, Hsu MJ, Liberator P, Misura AS, Motyl M, Nielsen Kahn J, Powles M, Racine F, Dragovic J, Fan W, Kirwan R, Lee S, Liu H, Mamai A, Nelson K, Peel M. Ibrexafungerp: an orally active β-1,3-glucan synthesis inhibitor. Bioorg Med Chem Lett. 2020 Nov 4:127661. doi: 10.1016/j.bmcl.2020.127661. Epub ahead of print. PMID: 33160023. 2: Apgar JM, Wilkening RR, Parker DL Jr, Meng D, Wildonger KJ, Sperbeck D, Greenlee ML, Balkovec JM, Flattery AM, Abruzzo GK, Galgoci AM, Giacobbe RA, Gill CJ, Hsu MJ, Liberator P, Misura AS, Motyl M, Kahn JN, Powles M, Racine F, Dragovic J, Fan W, Kirwan R, Lee S, Liu H, Mamai A, Nelson K, Peel M. MK-5204: An orally active β-1,3-glucan synthesis inhibitor. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127357. doi: 10.1016/j.bmcl.2020.127357. Epub 2020 Jun 19. PMID: 32738971.