MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 463486 | Name: MTMox32E

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MTMox32E is a novel Mithramycin A (MTM) 2'-oxime (MTMox) conjugate, displaying an 11-fold increase in plasma exposure and improved efficacy in an Ewing sarcoma xenograft.

Chemical Structure

MTMox32E
MTMox32E
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463486

Name: MTMox32E

CAS#: unknown

Chemical Formula: C75H100N4O28

Exact Mass: 1504.6524

Molecular Weight: 1505.63

Elemental Analysis: C, 59.83; H, 6.69; N, 3.72; O, 29.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
MTMox32E; MTMox-32E; MTMox 32E;
IUPAC/Chemical Name
methyl (2-((((1S,3R,4R,E)-1-((2S,3S)-3-(((2S,4R,5R,6R)-4-(((2S,4R,5S,6R)-4-(((2S,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-7-(((2S,4R,5R,6R)-4-(((2S,4R,5S,6R)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5,10-dihydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)-3,4-dihydroxy-1-methoxypentan-2-ylidene)amino)oxy)acetyl)-L-phenylalanyl-L-tryptophanate
InChi Key
FFTVRDGIUYWQPQ-SHWURPSFSA-N
InChi Code
InChI=1S/C75H100N4O28/c1-32-49(103-55-26-50(65(86)35(4)99-55)104-54-25-48(81)64(85)34(3)98-54)24-41-21-40-22-44(70(95-9)61(63(84)33(2)80)79-97-31-53(82)77-46(20-39-16-12-11-13-17-39)73(92)78-47(74(93)96-10)23-42-30-76-45-19-15-14-18-43(42)45)71(69(90)60(40)68(89)59(41)62(32)83)107-57-28-51(66(87)37(6)101-57)105-56-27-52(67(88)36(5)100-56)106-58-29-75(8,94)72(91)38(7)102-58/h11-19,21,24,30,33-38,44,46-48,50-52,54-58,63-67,70-72,76,80-81,83-89,91,94H,20,22-23,25-29,31H2,1-10H3,(H,77,82)(H,78,92)/b79-61+/t33-,34-,35-,36-,37-,38-,44+,46+,47+,48-,50-,51-,52-,54+,55+,56+,57+,58+,63+,64-,65-,66-,67+,70+,71+,72-,75+/m1/s1
SMILES Code
O=C(OC)[C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC3=CC=CC=C3)NC(CO/N=C([C@@H](O)[C@H](O)C)/[C@H]([C@@H]([C@@H]4O[C@H]5C[C@@H](O[C@H]6C[C@@H](O[C@H]7C[C@](C)(O)[C@H](O)[C@@H](C)O7)[C@@H](O)[C@@H](C)O6)[C@H](O)[C@@H](C)O5)CC8=C(C(O)=C9C(O)=C(C)C(O[C@H]%10C[C@@H](O[C@H]%11C[C@@H](O)[C@H](O)[C@@H](C)O%11)[C@H](O)[C@@H](C)O%10)=CC9=C8)C4=O)OC)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,505.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu Y, Eckenrode JM, Zhang Y, Zhang J, Hayden RC, Kyomuhangi A, Ponomareva LV, Cui Z, Rohr J, Tsodikov OV, Van Lanen SG, Shaaban KA, Leggas M, Thorson JS. Mithramycin 2'-Oximes with Improved Selectivity, Pharmacokinetics, and Ewing Sarcoma Antitumor Efficacy. J Med Chem. 2020 Nov 25;63(22):14067-14086. doi: 10.1021/acs.jmedchem.0c01526. Epub 2020 Nov 16. PMID: 33191745.