MedKoo Cat#: 412565 | Name: Centpropazine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Centpropazine is a new antidepressant with minimal anticholinergic effects in preclinical animal models

Chemical Structure

Centpropazine
CAS#91315-34-3

Theoretical Analysis

MedKoo Cat#: 412565

Name: Centpropazine

CAS#: 91315-34-3

Chemical Formula: C22H28N2O3

Exact Mass: 368.2100

Molecular Weight: 368.48

Elemental Analysis: C, 71.71; H, 7.66; N, 7.60; O, 13.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Centpropazine
IUPAC/Chemical Name
1-(4-(2-hydroxy-3-(4-phenylpiperazin-1-yl)propoxy)phenyl)propan-1-one
InChi Key
ZQPXSRTZFYHSFB-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H28N2O3/c1-2-22(26)18-8-10-21(11-9-18)27-17-20(25)16-23-12-14-24(15-13-23)19-6-4-3-5-7-19/h3-11,20,25H,2,12-17H2,1H3
SMILES Code
CCC(c1ccc(OCC(CN2CCN(c3ccccc3)CC2)O)cc1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 368.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dikshit M, Chalecka-Franaszek E, Nalepa I. Centpropazine affinity to cortical noradrenergic receptors and effect on their responsiveness in the rat. J Pharm Pharmacol. 1993 Mar;45(3):228-30. doi: 10.1111/j.2042-7158.1993.tb05540.x. PMID: 8097784. 2: Bhattaram VA, Paliwal JK, Gupta RC. Evaluation of pharmacokinetics, brain levels and protein binding of centpropazine in rats. Biopharm Drug Dispos. 2004 Mar;25(2):69-75. doi: 10.1002/bdd.385. PMID: 14872554. 3: Atul BV, Singh SK, Madhusudanan KP, Paliwal JK, Gupta RC. Isolation and characterization of metabolites of centpropazine in rat liver, intestine, and red blood cell homogenates. J Pharm Sci. 2002 Sep;91(9):2067-75. doi: 10.1002/jps.10196. PMID: 12210053. 4: Srivastava JS, Asthana OP, Singh H, Agarwal AK, Shah LP, Sharma KC, Gopinath PS, Srimal RC. Multicentric efficacy study of centpropazine and imipramine in depressed patients. Indian J Psychiatry. 1999 Jul;41(3):249-53. PMID: 21455398; PMCID: PMC2963000. 5: Atul BV, Paliwal JK, Gupta RC. Development and validation of a new high- performance liquid chromatographic assay of centpropazine, a new antidepressant compound, in serum. J Pharm Biomed Anal. 1999 Jul;20(3):449-57. doi: 10.1016/s0731-7085(99)00030-8. PMID: 10701961. 6: Atul BV, Paliwal JK, Gupta RC. Evaluation of absorbability of centpropazine in rats: in-situ and in-vivo appraoches. J Pharm Pharmacol. 2001 Jun;53(6):901-6. doi: 10.1211/0022357011776072. PMID: 11428668. 7: Gupta PP, Asthana OP, Tangri AN, Dhawan BN. Clinical pharmacological studies on centpropazine--a new antidepressant compound. Indian J Med Res. 1989 Oct;90:360-2. PMID: 2628304. 8: Srivastava JS, Gupta PP, Asthana OP, Nityanand S, Devi S, Doongaji DR, Sethi BB, Singh G, Srimal RC, Dhawan BN. Clinical efficacy of centporpazine-a new antidepressant. Indian J Psychiatry. 1992 Jul;34(3):260-3. PMID: 21776129; PMCID: PMC2982079. 9: Atul BV, Gupta RC. Determination of centpropazine and its metabolite in rat serum by high-performance liquid chromatography and fluorescence detection. J Chromatogr B Biomed Sci Appl. 2000 Oct 10;748(2):331-5. doi: 10.1016/s0378-4347(00)00345-5. PMID: 11087075. 10: Upreti N, Varma V, Mohan Rao VK. Effect of centpropazine on hepatic drug metabolizing enzymes in rat. Indian J Med Res. 1984 Jun;79:813-7. PMID: 6519706.