Synonym
Centpiperalone; Centpiperalone; NSC 327690
IUPAC/Chemical Name
4(1H)-Quinazolinone, 2-(1-piperazinyl)-, monoacetate
InChi Key
NGEOOZRNZHUVFZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H14N4O.C2H4O2/c17-11-9-3-1-2-4-10(9)14-12(15-11)16-7-5-13-6-8-16;1-2(3)4/h1-4,13H,5-8H2,(H,14,15,17);1H3,(H,3,4)
SMILES Code
O=C1N=C(N2CCNCC2)NC3=C1C=CC=C3.CC(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
290.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Chatterjee AK, Murthi PS, Mukherjee SK. Effect of centpiperalone in insulin deficient diabetes. Indian J Exp Biol. 1980 Sep;18(9):1005-8. PMID: 7009415.
2: Mukherjee SS, Murthi PS, Mukherjee SK. Studies on the mechanism of centpiperalone-induced hypoglycemia. Acta Diabetol Lat. 1976 Jan- Apr;13(1-2):8-19. doi: 10.1007/BF02591576. PMID: 788428.
3: Saxena AM, Murthy PS, Mukherjee SK. Mode of action of three structurally different hypoglycemic agents: a comparative study. Indian J Exp Biol. 1996 Apr;34(4):351-5. PMID: 8698425.
4: Srivastava PP, Murthy PS, Mukherjee SK. Efficacy of centpiperalone in combination with biguanide & sulfonylurea. Indian J Exp Biol. 1983 Jul;21(7):390-2. PMID: 6365752.
5: Mukerjee SS, Dey S, Bhaduri AP, Mukherjee SK. Tissue distribution of [3H]centpiperalone after oral administration. Indian J Biochem Biophys. 1980 Oct;17(5):399-401. PMID: 7251022.
6: Maitra SC, Murthi PS, Rastogi AK, Mukherjee SK. Diphenylhydantoin protection of centpiperalone induced insulin release from beta-cells. Exp Mol Pathol. 1980 Feb;32(1):43-51. doi: 10.1016/0014-4800(80)90041-6. PMID: 6985866.
7: Chatterjee AK, Mukherjee B, Mukherjee SK. Effect of centpiperalone, a new hypoglycemic agent on insulin biosynthesis & release from isolated pancreatic islets of rat. Indian J Exp Biol. 1982 Mar;20(3):270-2. PMID: 6749673.
8: Mukherjee SK, Husain ST. Effect of 2-piperazino-4(3H)-quinazolinone monoacetate on some aspects of carbohydrate metabolism of albino rats. Biochem Pharmacol. 1973 Sep 1;22(17):2205-6. doi: 10.1016/0006-2952(73)90122-6. PMID: 4733674.
9: Mukerjee SS, Sethi N, Roy AK, Srivastava GN, Mukherjee SK. Chronic toxicity studies of a hypoglycemic compound: centperalone in rats & rhesus monkeys. Indian J Exp Biol. 1979 Dec;17(12):1346-9. PMID: 120313.
