ADTL-EI1712 is a dual inhibitor of ERK1 and ERK5. It reduces ERK1 and ERK5 activity by 93.5% and 89.4%, respectively, but also inhibits ERK2 activity by 92.7%, in a panel of 100 kinases at 1 µM. ADTL-EI1712 inhibits proliferation of HL-60 and MKN74, but not HeLa, cancer cells. It reduces tumor growth and intratumor phosphorylation of ERK1/2 and ERK5 in an MKN74 mouse xenograft model when administered at a dose of 50 mg/kg per day.
MedKoo Cat#: 463477
Name: ADTL-EI1712
CAS#: 2414916-45-1
Chemical Formula: C22H18Cl2N4O2S2
Exact Mass: 504.0248
Molecular Weight: 505.43
Elemental Analysis: C, 52.28; H, 3.59; Cl, 14.03; N, 11.09; O, 6.33; S, 12.69
The following data is based on the product molecular weight 505.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
