GS493 is a cell-permeable, bioavailable, non-toxic p-nitro analog of PHPS1 that exhibits enhanced potency and selectivity. It acts as a phosphotyrosine mimetic, substrate-competitive and reversible catalytic domain inhibitor of SHP2. GS493 dose-dependently reverts HGF-stimulatd epithelial-mesenchymal transition of HPAF II cells and blocks human lung adenocarcinoma LXFA 526L anchorage-independent growth. GS493 is shown to significantly retard LXFA 526L xenografted tumor growth in mice.
MedKoo Cat#: 463476
Name: GS493
CAS#: unknown
Chemical Formula: C21H14N6O8S
Exact Mass: 510.0594
Molecular Weight: 510.44
Elemental Analysis: C, 49.41; H, 2.76; N, 16.46; O, 25.07; S, 6.28
The following data is based on the product molecular weight 510.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
