SAJ-310 | CAS#unknown | Hemoglobin S allosteric modulator

MedKoo Cat#: 463469 | Name: SAJ-310

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SAJ-310 is a hemoglobin S allosteric modulator. It is a novel potent antisickling agent.

Chemical Structure

SAJ-310

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463469

Name: SAJ-310

CAS#: unknown

Chemical Formula: C14H13NO3

Exact Mass: 243.0895

Molecular Weight: 243.26

Elemental Analysis: C, 69.12; H, 5.39; N, 5.76; O, 19.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SAJ-310; SAJ310; SAJ 310;

IUPAC/Chemical Name

5-methoxy-2-(pyridin-2-ylmethoxy)benzaldehyde

InChi Key

PZJIEYBOHZIPIN-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H13NO3/c1-17-13-5-6-14(11(8-13)9-16)18-10-12-4-2-3-7-15-12/h2-9H,10H2,1H3

SMILES Code

COC1=CC(C=O)=C(OCC2=NC=CC=C2)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 243.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Richter-Addo GB. A structure-guided approach to ameliorate sickle cell disease. Acta Crystallogr D Struct Biol. 2018 Nov 1;74(Pt 11):1039-1040. doi: 10.1107/S2059798318014997. Epub 2018 Oct 30. PMID: 30387762. 2: Deshpande TM, Pagare PP, Ghatge MS, Chen Q, Musayev FN, Venitz J, Zhang Y, Abdulmalik O, Safo MK. Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation. Acta Crystallogr D Struct Biol. 2018 Oct 1;74(Pt 10):956-964. doi: 10.1107/S2059798318009919. Epub 2018 Oct 2. PMID: 30289405; PMCID: PMC6173052. 3: Pagare PP, Ghatge MS, Musayev FN, Deshpande TM, Chen Q, Braxton C, Kim S, Venitz J, Zhang Y, Abdulmalik O, Safo MK. Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease. Bioorg Med Chem. 2018 May 15;26(9):2530-2538. doi: 10.1016/j.bmc.2018.04.015. Epub 2018 Apr 6. PMID: 29655608; PMCID: PMC5935541.