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MedKoo Cat#: 412550 | Name: Viomycin sulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Viomycin sulfate is a strongly basic peptide, antibiotic complex from several strains of Streptomyces. It is allergenic and toxic to kidneys and the labyrinth. Viomycin is used in tuberculosis as several different salts and in combination with other agents.

Chemical Structure

Viomycin sulfate
Viomycin sulfate
CAS#37883-00-4 (sulfate)

Theoretical Analysis

MedKoo Cat#: 412550

Name: Viomycin sulfate

CAS#: 37883-00-4 (sulfate)

Chemical Formula: C25H45N13O14S

Exact Mass: 783.2930

Molecular Weight: 783.77

Elemental Analysis: C, 38.31; H, 5.79; N, 23.23; O, 28.58; S, 4.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
32988-50-4 (free base); 37883-00-4 (sulfate)
Synonym
Viomycin sulfate; Viocin; UNII-LKO141R05V
IUPAC/Chemical Name
(S)-3,6-diamino-N-((3S,9S,12S,15S,Z)-3-((4R,6S)-2-amino-6-hydroxy-1,4,5,6-tetrahydropyrimidin-4-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide sulfate
InChi Key
AQONYROJHRNYQQ-QMAPKBLTSA-N
InChi Code
InChI=1S/C25H43N13O10.H2O4S/c26-3-1-2-10(27)4-16(41)32-12-6-30-23(47)18(11-5-17(42)37-24(28)36-11)38-20(44)13(7-31-25(29)48)33-21(45)14(8-39)35-22(46)15(9-40)34-19(12)43;1-5(2,3)4/h7,10-12,14-15,17-18,39-40,42H,1-6,8-9,26-27H2,(H,30,47)(H,32,41)(H,33,45)(H,34,43)(H,35,46)(H,38,44)(H3,28,36,37)(H3,29,31,48);(H2,1,2,3,4)/b13-7-;/t10-,11+,12-,14-,15-,17-,18-;/m0./s1
SMILES Code
NCCC[C@@H](CC(N[C@H]1CNC([C@H]([C@H]2C[C@@H](NC(N)=N2)O)NC(/C(NC([C@@H](NC([C@@H](NC1=O)CO)=O)CO)=O)=C/NC(N)=O)=O)=O)=O)N.OS(=O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 783.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Voigt R, Maa Bared AG. Zur chemischen und mikrobiologischen Erfassung der Liberation von Antituberkulotica aus Emulsions- und Suspensionssystemen. 2. Capreomycinsulfat, Viomycinsulfat und Kanamycinsulfat [Chemical and microbiological detection of liberation of antitubercular agents from emulsions and suspension systems. 2. Capreomycin sulfate, viomycin sulfate and kanamycin sulfate]. Pharmazie. 1970 May-Jun;25(5):342-4. German. PMID: 4318402. 2: Iscla I, Wray R, Wei S, Posner B, Blount P. Streptomycin potency is dependent on MscL channel expression. Nat Commun. 2014 Sep 10;5:4891. doi: 10.1038/ncomms5891. PMID: 25205267; PMCID: PMC4161981. 3: Masuda K, Yamada T. Effect of viomycin on dihydrostreptomycin binding to bacterial ribosomes. Biochim Biophys Acta. 1976 Jul 16;435(4):333-9. doi: 10.1016/0005-2787(76)90199-4. PMID: 60132. 4: RYSEBAERT J. Note sur l'emploi du sulfate de viomycine dans le traitement de la tuberculose pulmonaire [Note on the use of viomycin sulfate in the treatment of pulmonary tuberculosis]. Scalpel (Brux). 1955 Jul 9;108(28):725-9. French. PMID: 13246593. 5: Lightbown JW, Bond JM, Skegg JL. The second international reference preparation of viomycin. Bull World Health Organ. 1973;48(2):219-27. PMID: 4352612; PMCID: PMC2480998. 6: ANDREASSON G, EHRNER L, KRISTENSON A, LEVIN N. Några erfarenheter med viocinbehandling (viomycinsulfat) [Experiences with viocin therapy (viomycin sulfate)]. Sven Lakartidn. 1954 Nov 5;51(45):2848-54. Swedish. PMID: 13216622. 7: Nerlo H, Umer S. Trwałość roztworów wodnych siarczanu wiomycyny [Stability of aqueous solutions of viomycin sulfate]. Acta Pol Pharm. 1970;27(2):135-40. Polish. PMID: 4316267. 8: SCALFI GF, PONTIGGIA P, ROSSA G. Due anni di esperienza con viomicina- pantotenato-solfato (vionactan) nel trattamento della tubercolosi polmonare [Two years of experience with viomycin pantothenate-sulfate (vionactan) in the treatment of pulmonary tuberculosis]. Minerva Med. 1958 Sep 5;49(71):3343-56. Italian. PMID: 13600139. 9: ZELENKA M, JANCIK E. [Viomycin sulfate and viothenattoxic and side-effects in the treatment of chronic cases of tuberculosis]. Tuberkulosearzt. 1962 Aug;16:500-5. German. PMID: 14010064. 10: Kanda T, Igarashi M. Ultra-structural changes in vestibular sensory end organs after viomycin sulfate intoxication. Acta Otolaryngol. 1969 Dec;68(6):474-88. doi: 10.3109/00016486909121588. PMID: 4313880.

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