Synonym
Atenolol impurity I; Desmethyl atenolol
IUPAC/Chemical Name
2-(4-((2RS)-3-(Ethylamino)-2-hydroxypropoxy)phenyl)acetamide
InChi Key
BXEVWKYWEMQUHC-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H20N2O3/c1-2-15-8-11(16)9-18-12-5-3-10(4-6-12)7-13(14)17/h3-6,11,15-16H,2,7-9H2,1H3,(H2,14,17)
SMILES Code
CCNCC(O)COc1ccc(CC(=O)N)cc1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
252.31
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gong Y, McDonough CW, Beitelshees AL, Rouby NE, Hiltunen TP, O'Connell JR, Padmanabhan S, Langaee TY, Hall K, Schmidt SO, Curry RW Jr, Gums JG, Donner KM, Kontula KK, Bailey KR, Boerwinkle E, Takahashi A, Tanaka T, Kubo M, Chapman AB, Turner ST, Pepine CJ, Cooper-DeHoff RM, Johnson JA. PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. J Hypertens. 2015 Nov;33(11):2278-85. doi: 10.1097/HJH.0000000000000714. PubMed PMID: 26425837.
2: Yin J, Duan H, Shirasaka Y, Prasad B, Wang J. Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 (hOCT2) and Multidrug and Toxin Extrusion Proteins (hMATEs). Drug Metab Dispos. 2015 Sep 15. pii: dmd.115.066175. [Epub ahead of print] PubMed PMID: 26374172.
3: Di Salvo G, Castaldi B, Gala S, Baldini L, Del Gaizo F, D'Aiello FA, Mormile A, Rea A, Scognamiglio G, Pacileo G, Keating S, Fadel BM, Berrino L, Perna A, Russo MG, Calabrò R. Atenolol vs enalapril in young hypertensive patients after successful repair of aortic coarctation. J Hum Hypertens. 2015 Aug 20. doi: 10.1038/jhh.2015.87. [Epub ahead of print] PubMed PMID: 26290275.
