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MedKoo Cat#: 575088 | Name: ASTA-6496
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ASTA-6496 is the active metabolite form of the prodrug Cyclophosphamide. ASTA-6496 crosslinks DNA and induces T cell apoptosis independent of death receptor activation but activates mitochondrial death pathways through production of reactive oxygen species (ROS). Formulations containing the prodrug Cyclophosphamide are used to treat lymphomas and autoimmune disorders.

Chemical Structure

ASTA-6496
ASTA-6496
CAS#39800-16-3

Theoretical Analysis

MedKoo Cat#: 575088

Name: ASTA-6496

CAS#: 39800-16-3

Chemical Formula: C7H15Cl2N2O4P

Exact Mass: 292.0146

Molecular Weight: 293.08

Elemental Analysis: C, 28.69; H, 5.16; Cl, 24.19; N, 9.56; O, 21.84; P, 10.57

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
4-hydroperoxy Cyclophosphamide; 4-OOH-CY; ASTA 6496; ASTA-6496; ASTA6496
IUPAC/Chemical Name
2-(bis(2-chloroethyl)amino)-4-hydroperoxy-1,3,2-oxazaphosphinane 2-oxide
InChi Key
VPAWVRUHMJVRHU-UHFFFAOYSA-N
InChi Code
InChI=1S/C7H15Cl2N2O4P/c8-2-4-11(5-3-9)16(13)10-7(15-12)1-6-14-16/h7,12H,1-6H2,(H,10,13)
SMILES Code
OOC1CCOP(=O)(N1)N(CCCl)CCCl
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 293.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Strauss, G., Westhoff, M.-A., Fischer-Posovszky, P., et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ. 15(2), 332-343 (2008). 2. Ahmed, A.R., and Hombal, S.M. Cyclophosphamide (Cytoxan). A review on relevant pharmacology and clinical uses. J. Am. Acad. Dermatol. 11(6), 1115-1126 (1984). 3. Appel, G.B. New and future therapies for lupus nephritis. Cleve. Clin. J. Med. 79(2), 134-140 (2012).