MedKoo Cat#: 412505 | Name: Cefdaloxime

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cefdaloxime is a third-generation cephalosporin antibiotic and a new active component of the HR-916 ester.

Chemical Structure

Cefdaloxime
Cefdaloxime
CAS#80195-36-4

Theoretical Analysis

MedKoo Cat#: 412505

Name: Cefdaloxime

CAS#: 80195-36-4

Chemical Formula: C14H15N5O6S2

Exact Mass: 413.0464

Molecular Weight: 413.42

Elemental Analysis: C, 40.67; H, 3.66; N, 16.94; O, 23.22; S, 15.51

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Synonym
Cefdaloxime; RU-29246; RU29246; RU 29246
IUPAC/Chemical Name
(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChi Key
HOGISBSFFHDTRM-GHXIOONMSA-N
InChi Code
InChI=1S/C14H15N5O6S2/c1-25-2-5-3-26-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24)6-4-27-14(15)16-6/h4,8,12,24H,2-3H2,1H3,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1
SMILES Code
COCC1=C(C(O)=O)N2[C@@H]([C@@H](C2=O)NC(/C(c3nc(N)sc3)=N\O)=O)SC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 413.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jones RN, Erwin ME. Haemophilus test medium interpretive criteria for disk diffusion susceptibility tests with cefdinir, cefetamet, cefmetazole, cefpodoxime, cefdaloxime (RU29246, HR-916 metabolite), and trospectomycin. Diagn Microbiol Infect Dis. 1992 Nov-Dec;15(8):693-701. doi: 10.1016/0732-8893(92)90073-3. PMID: 1478050. 2: Jones RN, Erwin ME. Preliminary disk diffusion susceptibility testing criteria for cefdaloxime (RU29246, HR-916 metabolite), a new orally administered cephalosporin. J Clin Microbiol. 1992 May;30(5):1297-300. doi: 10.1128/JCM.30.5.1297-1300.1992. PMID: 1583135; PMCID: PMC265269. 3: Sader HS, Runyon BA, Erwin ME, Jones RN. Antimicrobial activity of 11 newer and investigational drugs tested against aerobic isolates from spontaneous bacterial peritonitis. Diagn Microbiol Infect Dis. 1995 Feb;21(2):105-10. doi: 10.1016/0732-8893(94)00148-p. PMID: 7628189. 4: Buschelman BJ, Jones RN, Bale MJ. Effects of blood medium supplements on activities of newer cephalosporins tested against enterococci. J Clin Microbiol. 1994 Feb;32(2):565-7. doi: 10.1128/JCM.32.2.565-567.1994. PMID: 8150978; PMCID: PMC263080.