MedKoo Cat#: 463429 | Name: CCG-203586

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CCG-203586 is a novel potent glucosylceramide synthase (GCS) inhibitor.

Chemical Structure

CCG-203586
CCG-203586
CAS#1430611-23-6

Theoretical Analysis

MedKoo Cat#: 463429

Name: CCG-203586

CAS#: 1430611-23-6

Chemical Formula: C26H32N2O4

Exact Mass: 436.2362

Molecular Weight: 436.55

Elemental Analysis: C, 71.53; H, 7.39; N, 6.42; O, 14.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
CCG-203586; CCG203586; CCG 203586; EtDO-PIP2; EtDOPIP2; EtDO PIP2;
IUPAC/Chemical Name
2-(2,3-dihydro-1H-inden-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)acetamide
InChi Key
WXPGOGVMRCVPDZ-ATIYNZHBSA-N
InChi Code
InChI=1S/C26H32N2O4/c29-25(15-18-13-19-5-1-2-6-20(19)14-18)27-22(17-28-9-3-4-10-28)26(30)21-7-8-23-24(16-21)32-12-11-31-23/h1-2,5-8,16,18,22,26,30H,3-4,9-15,17H2,(H,27,29)/t22-,26-/m1/s1
SMILES Code
O=C(N[C@H](CN1CCCC1)[C@@H](C2=CC=C(OCCO3)C3=C2)O)CC4CC5=C(C=CC=C5)C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 436.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Arthur JR, Wilson MW, Larsen SD, Rockwell HE, Shayman JA, Seyfried TN. Ethylenedioxy-PIP2 oxalate reduces ganglioside storage in juvenile Sandhoff disease mice. Neurochem Res. 2013 Apr;38(4):866-75. doi: 10.1007/s11064-013-0992-5. Epub 2013 Feb 16. PMID: 23417430; PMCID: PMC6554746. 2: Larsen SD, Wilson MW, Abe A, Shu L, George CH, Kirchhoff P, Showalter HD, Xiang J, Keep RF, Shayman JA. Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain. J Lipid Res. 2012 Feb;53(2):282-91. doi: 10.1194/jlr.M021261. Epub 2011 Nov 4. PMID: 22058426; PMCID: PMC3269155.