Synonym
Pyrithione cadmium; CdPT; Cadmium PT
IUPAC/Chemical Name
cadmium(II) 2-thioxopyridin-1(2H)-olate
InChi Key
YSWAWAYOPDDQJN-UHFFFAOYSA-N
InChi Code
InChI=1S/2C5H4NOS.Cd/c2*7-6-4-2-1-3-5(6)8;/h2*1-4H;/q2*-1;+2
SMILES Code
[O-]N1C=CC=CC1=S.[O-]N2C=CC=CC2=S.[Cd+2]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
364.72
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Chen X, Wu J, Yang Q, Zhang X, Zhang P, Liao S, He Z, Wang X, Zhao C, Liu J. Cadmium pyrithione suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase. Biometals. 2018 Feb;31(1):29-43. doi: 10.1007/s10534-017-0062-6. Epub 2017 Nov 3. PMID: 29098502.
2: Namdarghanbari MA, Bertling J, Krezoski S, Petering DH. Toxic metal proteomics: reaction of the mammalian zinc proteome with Cd²⁺. J Inorg Biochem. 2014 Jul;136:115-21. doi: 10.1016/j.jinorgbio.2014.01.014. Epub 2014 Jan 25. PMID: 24529759; PMCID: PMC4517600.
3: Rigobello MP, Messori L, Marcon G, Agostina Cinellu M, Bragadin M, Folda A, Scutari G, Bindoli A. Gold complexes inhibit mitochondrial thioredoxin reductase: consequences on mitochondrial functions. J Inorg Biochem. 2004 Oct;98(10):1634-41. doi: 10.1016/j.jinorgbio.2004.04.020. PMID: 15458826.
4: Jasim S, Tjälve H. Effect of zinc pyridinethione on the tissue disposition of nickel and cadmium in mice. Acta Pharmacol Toxicol (Copenh). 1986 Sep;59(3):204-8. doi: 10.1111/j.1600-0773.1986.tb00155.x. PMID: 3799198.
5: Koutsaftis A, Aoyama I. The interactive effects of binary mixtures of three antifouling biocides and three heavy metals against the marine algae Chaetoceros gracilis. Environ Toxicol. 2006 Aug;21(4):432-9. doi: 10.1002/tox.20202. PMID: 16841316.
6: Jasim S, Tjälve H. Effects of sodium pyridinethione on the uptake and distribution of nickel, cadmium and zinc in pregnant and non-pregnant mice. Toxicology. 1986 Mar;38(3):327-50. doi: 10.1016/0300-483x(86)90148-4. PMID: 3952760.
