CDD-0102 (free base) | CAS# 146422-58-4 (free base) | selectively activates M1 muscarinic receptors

MedKoo Cat#: 412474 | Name: CDD-0102 (free base)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CDD-0102 (free base) is a small molecule that selectively activates M1 muscarinic receptors, exhibits a low side effect profile at doses that enhance memory function in rodents, and displays neuroprotective effects in cell culture.

Chemical Structure

CDD-0102 (free base)

CAS#CAS# 146422-58-4 (free base)

Theoretical Analysis

MedKoo Cat#: 412474

Name: CDD-0102 (free base)

CAS#: CAS# 146422-58-4 (free base)

Chemical Formula: C8H12N4O

Exact Mass: 180.1011

Molecular Weight: 180.21

Elemental Analysis: C, 53.32; H, 6.71; N, 31.09; O, 8.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

CAS# 146422-58-4 (free base); 1196130-86-5 (HCl)

Synonym

CDD-0102; CDD0102; CDD 0102; CDD102A; CDD 102A; CDD-102A

IUPAC/Chemical Name

3-ethyl-5-(1,4,5,6-tetrahydropyrimidin-5-yl)-1,2,4-oxadiazole

InChi Key

IPKFWLRXFSUTDZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C8H12N4O/c1-2-7-11-8(13-12-7)6-3-9-5-10-4-6/h5-6H,2-4H2,1H3,(H,9,10)

SMILES Code

CCc1nc(C2CNC=NC2)on1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 180.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bachmann K, Telang U, Byers J, Hoss W. The processing of the selective M1 agonist CDD-0102-J by human hepatic drug metabolizing enzymes. Am J Ther. 2005 Jul-Aug;12(4):300-5. doi: 10.1097/01.pgp.0000145356.05787.19. PMID: 16041192. 2: Messer WS Jr. The utility of muscarinic agonists in the treatment of Alzheimer's disease. J Mol Neurosci. 2002 Aug-Oct;19(1-2):187-93. doi: 10.1007/s12031-002-0031-5. PMID: 12212779. 3: Messer WS Jr, Rajeswaran WG, Cao Y, Zhang HJ, el-Assadi AA, Dockery C, Liske J, O'Brien J, Williams FE, Huang XP, Wroblewski ME, Nagy PI, Peseckis SM. Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors. Pharm Acta Helv. 2000 Mar;74(2-3):135-40. doi: 10.1016/s0031-6865(99)00026-6. PMID: 10812950.