Cavidine | CAS# 32728-75-9

MedKoo Cat#: 412457 | Name: Cavidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cavidine is isolated from Corydalis impatiens and have been exhibited to have potent anti-inflammatory effects in previous studies.

Chemical Structure

Cavidine

CAS#32728-75-9

Theoretical Analysis

MedKoo Cat#: 412457

Name: Cavidine

CAS#: 32728-75-9

Chemical Formula: C21H23NO4

Exact Mass: 353.1627

Molecular Weight: 353.42

Elemental Analysis: C, 71.37; H, 6.56; N, 3.96; O, 18.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Cavidine

IUPAC/Chemical Name

(6S,6aR)-8,9-dimethoxy-6-methyl-6,6a,11,14-tetrahydro-12H-[1,3]dioxolo[4,5-h]isoquinolino[2,1-b]isoquinoline

InChi Key

JTZZGWPIBBTYNE-FKIZINRSSA-N

InChi Code

InChI=1S/C21H23NO4/c1-12-14-4-5-17-21(26-11-25-17)16(14)10-22-7-6-13-8-18(23-2)19(24-3)9-15(13)20(12)22/h4-5,8-9,12,20H,6-7,10-11H2,1-3H3/t12-,20+/m0/s1

SMILES Code

COc1c(OC)cc2c(CCN3Cc4c([C@@H]([C@@H]32)C)ccc5c4OCO5)c1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 353.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Niu X, Liu F, Li W, Zhi W, Zhang H, Wang X, He Z. Cavidine Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via NF-κB Signaling Pathway in vivo and in vitro. Inflammation. 2017 Aug;40(4):1111-1122. doi: 10.1007/s10753-017-0553-1. PMID: 28365871. 2: Li W, Zhang H, Niu X, Wang X, Wang Y, He Z, Yao H. Effects and mechanisms of cavidine protecting mice against LPS-induced endotoxic shock. Toxicol Appl Pharmacol. 2016 Aug 15;305:46-54. doi: 10.1016/j.taap.2016.05.021. Epub 2016 May 31. PMID: 27260672. 3: Li W, Wang X, Zhang H, He Z, Zhi W, Liu F, Wang Y, Niu X. Anti-ulcerogenic effect of cavidine against ethanol-induced acute gastric ulcer in mice and possible underlying mechanism. Int Immunopharmacol. 2016 Sep;38:450-9. doi: 10.1016/j.intimp.2016.06.016. Epub 2016 Jul 2. PMID: 27380619. 4: Niu X, Zhang H, Li W, Mu Q, Yao H, Wang Y. Anti-inflammatory effects of cavidine in vitro and in vivo, a selective COX-2 inhibitor in LPS-induced peritoneal macrophages of mouse. Inflammation. 2015 Apr;38(2):923-33. doi: 10.1007/s10753-014-0054-4. PMID: 25373916. 5: Niu X, Zhang H, Li W, Wang Y, Mu Q, Wang X, He Z, Yao H. Protective effect of cavidine on acetic acid-induced murine colitis via regulating antioxidant, cytokine profile and NF-κB signal transduction pathways. Chem Biol Interact. 2015 Sep 5;239:34-45. doi: 10.1016/j.cbi.2015.06.026. Epub 2015 Jun 20. PMID: 26102009. 6: Ninomiya I, Naito T, Takasugi H. Photocyclisation of enamides. Part VIII. Synthesis of 13-methyl-berbines; total synthesis of (+/-)-cavidine. J Chem Soc Perkin 1. 1975;(18):1791-5. doi: 10.1002/chin.197549458. PMID: 1238410. 7: Niu X, Li W, Xu H, Liu X, Qi L. Simultaneous quantification of 11 isoquinoline alkaloids in Corydalis impatiens (Pall.) Fisch by HPLC. J Sep Sci. 2013 Jul;36(13):2090-5. doi: 10.1002/jssc.201300036. Epub 2013 Jun 10. PMID: 23610009. 8: Bhakuni DS, Chaturvedi R. The alkaloids of Corydalis meifolia. J Nat Prod. 1983 Jul-Aug;46(4):466-70. doi: 10.1021/np50028a006. PMID: 6631434. 9: Yu J, Liu Q, Lu X, Li X, Li N, Liu B, Huang F, Qiu Z. Inhibitory and inductive effects of Corydalis saxicola Bunting total alkaloids (CSBTA) on cytochrome P450s in rats. Phytother Res. 2018 Sep;32(9):1818-1827. doi: 10.1002/ptr.6117. Epub 2018 May 28. PMID: 29806105. 10: Kiryakov HG, Iskrenova E, Daskalova E, Kuzmanov B, Evstatieva L. Alkaloids of Corydalis slivenensis. Planta Med. 1982 Mar;44(3):168-70. doi: 10.1055/s-2007-971432. PMID: 17402105.

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Description:

Chemical Structure

Theoretical Analysis

Price and Availability

Preparing Stock Solutions

View History

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