MedKoo Cat#: 575049 | Name: Asimilobine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Asimilobine is an inhibitor of dopamine biosynthesis and a serotonergic receptor antagonist.

Chemical Structure

Asimilobine
Asimilobine
CAS#6871-21-2

Theoretical Analysis

MedKoo Cat#: 575049

Name: Asimilobine

CAS#: 6871-21-2

Chemical Formula: C17H17NO2

Exact Mass: 267.1259

Molecular Weight: 267.33

Elemental Analysis: C, 76.38; H, 6.41; N, 5.24; O, 11.97

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Asimilobine
IUPAC/Chemical Name
4H-Dibenzo(de,g)quinolin-2-ol, 5,6,6a,7-tetrahydro-1-methoxy-, (R)-
InChi Key
NBDNEUOVIJYCGZ-CYBMUJFWSA-N
InChi Code
InChI=1S/C17H17NO2/c1-20-17-14(19)9-11-6-7-18-13-8-10-4-2-3-5-12(10)16(17)15(11)13/h2-5,9,13,18-19H,6-8H2,1H3/t13-/m1/s1
SMILES Code
COc1c(O)cc2CCN[C@@H]3Cc4ccccc4c1c23
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 267.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Jin CM, Lee JJ, Kim YK, Ryu SY, Lim SC, Hwang BY, Lee CK, Lee MK. Effects of asimilobine on dopamine biosynthesis and l-DOPA-induced cytotoxicity in PC12 cells. J Asian Nat Prod Res. 2008 Jul-Aug;10(7-8):747-55. doi: 10.1080/10286020802030892. PMID: 18696327. 2. Yano M, Nakashima S, Oda Y, Nakamura S, Matsuda H. BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells. J Nat Med. 2020 Jan;74(1):212-218. doi: 10.1007/s11418-019-01368-7. Epub 2019 Nov 9. PMID: 31707550. 3. Nugraha AS, Damayanti YD, Wangchuk P, Keller PA. Anti-Infective and Anti-Cancer Properties of the Annona Species: Their Ethnomedicinal Uses, Alkaloid Diversity, and Pharmacological Activities. Molecules. 2019 Dec 3;24(23):4419. doi: 10.3390/molecules24234419. PMID: 31816948; PMCID: PMC6930583.