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MedKoo Cat#: 412448 | Name: Cationomycin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cationomycin is a polyether ionophore antibiotic produced by Actinomadura Nov. sp

Chemical Structure

Cationomycin
Cationomycin
CAS#80394-65-6

Theoretical Analysis

MedKoo Cat#: 412448

Name: Cationomycin

CAS#: 80394-65-6

Chemical Formula: C45H70O15

Exact Mass: 850.4715

Molecular Weight: 851.04

Elemental Analysis: C, 63.51; H, 8.29; O, 28.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Cationomycin; BRN6263205; BRN-6263205; BRN 6263205
IUPAC/Chemical Name
2-hydroxy-4-(9-hydroxy-2-((2S,2'R,2''S,3S,3'S,3''S,5'R,5''S)-5''-((S)-1-hydroxypropyl)-3-methoxy-2,3',3'',5''-tetramethyldodecahydro-[2,2':5',2''-terfuran]-5-yl)-2,3,8-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)-3-((2-hydroxy-4-methoxy-6-methylbenzoyl)oxy)-2-methylbutanoic acid
InChi Key
SGLQOFJJLQBZBE-MSFHLGAUSA-N
InChi Code
InChI=1S/C45H70O15/c1-13-32(48)41(7)19-24(4)37(59-41)31-15-23(3)38(55-31)44(10)34(54-12)18-35(58-44)43(9)25(5)20-45(60-43)21-29(47)26(6)30(57-45)17-33(42(8,52)40(50)51)56-39(49)36-22(2)14-27(53-11)16-28(36)46/h14,16,23-26,29-35,37-38,46-48,52H,13,15,17-21H2,1-12H3,(H,50,51)/t23-,24-,25?,26?,29?,30?,31+,32-,33?,34-,35?,37-,38+,41-,42?,43?,44-,45?/m0/s1
SMILES Code
CC[C@@H]([C@@]1(C[C@@H]([C@@H]([C@H]2C[C@@H]([C@H]([C@]3(OC(C4(OC5(CC(C(C(O5)CC(C(O)(C(O)=O)C)OC(c6c(O)cc(OC)cc6C)=O)C)O)CC4C)C)C[C@@H]3OC)C)O2)C)O1)C)C)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 851.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gibot S, Jeminet G, Juillard J, Gumila C, Ancelin ML, Vial H, Delort AM. Cationomycin and monensin partition between serum proteins and erythrocyte membrane: consequences for Na+ and K+ transport and antimalarial activities. Arch Biochem Biophys. 1999 Mar 15;363(2):361-72. doi: 10.1006/abbi.1999.1101. PMID: 10068460. 2: Delort AM, Jeminet G, Sareth S, Riddle FG. Ionophore properties of cationomycin in large unilamellar vesicles studied by 23Na- and 39K-NMR. Chem Pharm Bull (Tokyo). 1998 Oct;46(10):1618-20. doi: 10.1248/cpb.46.1618. PMID: 9810697. 3: Nakamura G, Isono K. A new species of Actinomadura producing a polyether antibiotic, cationomycin. J Antibiot (Tokyo). 1983 Nov;36(11):1468-72. doi: 10.7164/antibiotics.36.1468. PMID: 6654756. 4: Gomez L, Jouany JP. Effects of lasalocid and cationomycin on the evolution of certain parameters in the blood plasma of sheep. Arch Tierernahr. 1994;46(3):283-93. doi: 10.1080/17450399409381778. PMID: 7619003. 5: Nakamura G, Kobayashi K, Sakurai T, Isono K. Cationomycin, a new polyether ionophore antibiotic produced by Actinomadura Nov. sp. J Antibiot (Tokyo). 1981 Nov;34(11):1513-4. doi: 10.7164/antibiotics.34.1513. PMID: 7319913. 6: Gomez L, Jouany JP, Lefaivre J. Influence of lasalocid, cationomycin and feeding frequency on the postprandial kinetics of some plasma parameters in the rumen vein, portal vein and mesenteric artery of sheep. Arch Tierernahr. 1995;48(4):357-66. doi: 10.1080/17450399509381855. PMID: 8585807. 7: Gomez L, Lallès JP, Bogaërt C, Poncet C. Kinetics of particulate and solute marker passage in sheep supplemented with cationomycin and lasalocid antibiotics. Comparisons among methods for calculating mean retention time. Reprod Nutr Dev. 1992;32(2):173-90. doi: 10.1051/rnd:19920210. PMID: 1388694. 8: Hillaire MC, Jouany JP, Gaboyard C, Jeminet G. In vitro study of the effect of different ionophore antibiotics and of certain derivatives on rumen fermentation and on protein nitrogen degradation. Reprod Nutr Dev. 1989;29(3):247-57. doi: 10.1051/rnd:19890302. PMID: 2590388.