Calcitonin | CAS# 47931-85-1 | Calcium-Regulating Hormone

MedKoo Cat#: 412424 | Name: Calcitonin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells of the thyroid gland in humans, and in many other animals in the ultimopharyngeal body. It acts to reduce blood calcium, opposing the effects of parathyroid hormone. Calcitonin has been found in fish, reptiles, birds, and mammals.

Chemical Structure

Calcitonin

CAS#47931-85-1

Theoretical Analysis

MedKoo Cat#: 412424

Name: Calcitonin

CAS#: 47931-85-1

Chemical Formula: C145H240N44O48S2

Exact Mass: 3429.7133

Molecular Weight: 3431.89

Elemental Analysis: C, 50.75; H, 7.05; N, 17.96; O, 22.38; S, 1.87

Price and Availability

Size	Price	Availability
5mg	USD 450.00	2 Weeks
10mg	USD 750.00	2 Weeks
25mg	USD 1,450.00	2 Weeks

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Synonym

Calcitonin; Astronin; Osteobion; Steocin; TZ-CT

IUPAC/Chemical Name

(4S)-4-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(4R,7S,10S,13S,16S,19S,22R)-22-amino-16-(2-amino-2-oxoethyl)-7-[(1R)-1-hydroxyethyl]-10,19-bis(hydroxymethyl)-13-(2-methylpropyl)-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S,3R)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S,3R)-1-[[2-[[(2S)-1-[[2-[[(2S,3R)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid

InChi Key

BBBFJLBPOGFECG-VJVYQDLKSA-N

InChi Code

InChI=1S/C145H240N44O48S2/c1-65(2)45-86(175-139(232)110(70(11)12)183-136(229)99-63-239-238-62-79(148)117(210)178-96(59-191)134(227)174-92(52-104(151)202)131(224)172-90(49-69(9)10)129(222)180-98(61-193)135(228)187-114(74(16)197)142(235)181-99)118(211)158-55-106(204)162-80(25-18-20-40-146)120(213)169-89(48-68(7)8)128(221)179-97(60-192)133(226)167-83(34-37-102(149)200)122(215)165-85(36-39-109(207)208)123(216)171-88(47-67(5)6)127(220)173-91(51-77-54-156-64-161-77)130(223)164-81(26-19-21-41-147)121(214)170-87(46-66(3)4)126(219)166-84(35-38-103(150)201)125(218)186-113(73(15)196)141(234)177-94(50-76-30-32-78(199)33-31-76)143(236)189-44-24-29-101(189)137(230)168-82(27-22-42-157-145(154)155)124(217)185-112(72(14)195)140(233)176-93(53-105(152)203)132(225)184-111(71(13)194)138(231)160-56-107(205)163-95(58-190)119(212)159-57-108(206)182-115(75(17)198)144(237)188-43-23-28-100(188)116(153)209/h30-33,54,64-75,79-101,110-115,190-199H,18-29,34-53,55-63,146-148H2,1-17H3,(H2,149,200)(H2,150,201)(H2,151,202)(H2,152,203)(H2,153,209)(H,156,161)(H,158,211)(H,159,212)(H,160,231)(H,162,204)(H,163,205)(H,164,223)(H,165,215)(H,166,219)(H,167,226)(H,168,230)(H,169,213)(H,170,214)(H,171,216)(H,172,224)(H,173,220)(H,174,227)(H,175,232)(H,176,233)(H,177,234)(H,178,210)(H,179,221)(H,180,222)(H,181,235)(H,182,206)(H,183,229)(H,184,225)(H,185,217)(H,186,218)(H,187,228)(H,207,208)(H4,154,155,157)/t71-,72-,73-,74-,75-,79+,80+,81+,82+,83+,84+,85+,86+,87+,88+,89+,90+,91+,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,110+,111+,112+,113+,114+,115+/m1/s1

SMILES Code

OC(C=C1)=CC=C1C[C@H](NC([C@H]([C@H](O)C)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H]2NC([C@](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC2)N)=O)CO)=O)CC(N)=O)=O)CC(C)C)=O)CO)=O)([H])[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)=O)=O)C(N4[C@@H](CCC4)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CO)C(NCC(N[C@@H]([C@H](O)C)C(N5[C@@H](CCC5)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 3,431.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Srinivasan A, Wong FK, Karponis D. Calcitonin: A useful old friend. J Musculoskelet Neuronal Interact. 2020 Dec 1;20(4):600-609. PMID: 33265089; PMCID: PMC7716677. 2: Sexton PM, Findlay DM, Martin TJ. Calcitonin. Curr Med Chem. 1999 Nov;6(11):1067-93. PMID: 10519914. 3: Potts JT Jr, Niall HD, Deftos LJ. Calcitonin. Curr Top Exp Endocrinol. 1971;1:151-73. doi: 10.1016/b978-0-12-153201-7.50011-9. PMID: 4949942. 4: Anast CS, Conaway HH. Calcitonin. Clin Orthop Relat Res. 1972 May;84:207-62. doi: 10.1097/00003086-197205000-00034. PMID: 4555851. 5: Itabashi A. [Calcitonin]. Nihon Rinsho. 1998 Jun;56(6):1511-7. Japanese. PMID: 9648474. 6: Silverman SL. Nasal calcitonin. Endocrine. 1997 Apr;6(2):199-202. doi: 10.1007/BF02738965. PMID: 9225136. 7: Reginster JY. La calcitonine [Calcitonin]. Rev Med Liege. 1996 Jan;51(1):116-9. French. PMID: 8701121. 8: Neundorf I, Beck-Sickinger AG. Calcitonin-derived carrier peptides. Curr Pharm Des. 2005;11(28):3661-9. doi: 10.2174/138161205774580723. PMID: 16305502. 9: Martin TJ. Calcitonin, an update. Bone. 1999 May;24(5 Suppl):63S-65S. doi: 10.1016/s8756-3282(99)00068-x. PMID: 10321932. 10: Franceschini R, Cataldi A, Cianciosi P, Garibaldi A, Corsini G, Barreca T, Rolandi E. Calcitonin and beta-endorphin secretion. Biomed Pharmacother. 1993;47(8):305-9. doi: 10.1016/0753-3322(93)90079-z. PMID: 8061253. 11: Muñoz-Torres M, Alonso G, Raya MP. Calcitonin therapy in osteoporosis. Treat Endocrinol. 2004;3(2):117-32. doi: 10.2165/00024677-200403020-00006. PMID: 15743107. 12: Maricic MJ. Oral calcitonin. Curr Osteoporos Rep. 2012 Mar;10(1):80-5. doi: 10.1007/s11914-011-0084-x. PMID: 22281725. 13: Calcitonin. Br Med J. 1968 Jul 6;3(5609):3-4. PMID: 5661913; PMCID: PMC1991274. 14: Body JJ. Calcitonin: what is new in 1992? Acta Clin Belg. 1992;47(2):77-81. doi: 10.1080/17843286.1992.11718213. PMID: 1321540. 15: Austin LA, Heath H 3rd. Calcitonin: physiology and pathophysiology. N Engl J Med. 1981 Jan 29;304(5):269-78. doi: 10.1056/NEJM198101293040505. PMID: 7003392. 16: Copp DH. Calcitonin. Adv Intern Med. 1968;14:55-82. PMID: 4883746. 17: Rico Lenza H. La calcitonina hoy [Calcitonin today]. Rev Clin Esp. 2003 Mar;203(3):115-7. Spanish. doi: 10.1157/13044919. PMID: 12646078. 18: Kanis JA. Calcitonin in osteoporosis. Bone. 2002 May;30(5 Suppl):65S-66S. doi: 10.1016/s8756-3282(02)00712-3. PMID: 12008160. 19: Vik A, Yatham LN. Calcitonin and bipolar disorder: a hypothesis revisited. J Psychiatry Neurosci. 1998 Mar;23(2):109-17. PMID: 9549251; PMCID: PMC1188909. 20: Kraiem A, el May M, Guermazi F, Mtimet S. La calcitonine [Calcitonin]. Tunis Med. 1989 Aug-Sep;67(8-9):473-9. French. PMID: 2678643.