Synonym
Sodium gentisate; NSC8512; NSC-8512; NSC 8512
IUPAC/Chemical Name
sodium 2,5-dihydroxybenzoate
InChi Key
MOIJZWWOFOQFMH-UHFFFAOYSA-M
InChi Code
InChI=1S/C7H6O4.Na/c8-4-1-2-6(9)5(3-4)7(10)11;/h1-3,8-9H,(H,10,11);/q;+1/p-1
SMILES Code
Oc1cc(C([O-])=O)c(O)cc1.[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
176.10
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Grzesik M, Bartosz G, Stefaniuk I, Pichla M, Namieśnik J, Sadowska-Bartosz I. Dietary antioxidants as a source of hydrogen peroxide. Food Chem. 2019 Apr 25;278:692-699. doi: 10.1016/j.foodchem.2018.11.109. Epub 2018 Nov 30. PMID: 30583431.
2: MOREL A, JOSSERAND A, CHAPPET J. Existence d'une rétention du gentisate de soude dans l'organisme des cancéreux; relation possible avec la pathologie du collagène [Sodium gentisate retention in a cancerous organism; possible relation with collagen pathology]. C R Seances Soc Biol Fil. 1952 Sep;146(17-18):1341-2. Undetermined Language. PMID: 13020162.
3: Trivedi VD, Bharadwaj A, Varunjikar MS, Singha AK, Upadhyay P, Gautam K, Phale PS. Insights into metabolism and sodium chloride adaptability of carbaryl degrading halotolerant Pseudomonas sp. strain C7. Arch Microbiol. 2017 Aug;199(6):907-916. doi: 10.1007/s00203-017-1363-4. Epub 2017 Apr 3. PMID: 28374062.
4: Huang L, Hu H, Tang H, Liu Y, Xu P, Shi J, Lin K, Luo Q, Cui C. Identification and Characterization of a Novel Gentisate 1,2-Dioxygenase Gene from a Halophilic Martelella Strain. Sci Rep. 2015 Sep 23;5:14307. doi: 10.1038/srep14307. PMID: 26394696; PMCID: PMC4585797.
5: Meade BW, Smith MJ. The Estimation of Sodium Gentisate in Plasma and Urine. J Clin Pathol. 1951 May;4(2):226-30. doi: 10.1136/jcp.4.2.226. PMID: 16810927; PMCID: PMC1023403.
6: GENTISATE de sodium, dihydroxy-2,5 benzoate de sodium [Sodium gentisate, 2,5-dihydroxy sodium benzoate]. Ann Pharm Fr. 1951 Nov;9(11):690-4. Undetermined Language. PMID: 14915294.
7: THIEBLOT L, SIMON E, LAFORET J, BERTHELAY J. Influence du salicylate et du gentisate de sodium sur la perméabilité de la membrane synoviale de l'articulation [Influence of sodium salicylate and of sodium gentisate on the permeability of synovial membranes]. C R Hebd Seances Acad Sci. 1951 Apr 23;232(17):1612-4. Undetermined Language. PMID: 14831267.
8: SMITH MJ. The estimation of sodium gentisate in tablets and injections. J Pharm Pharmacol. 1950 Jul;2(7):439-43. doi: 10.1111/j.2042-7158.1950.tb12957.x. PMID: 15429034.
9: CULIK J, BEJSOVEC M. [Effect on growth of sodium salicylate and sodium gentisate. II]. Cas Lek Cesk. 1961 Oct 20;100:1332-5. Czech. PMID: 13882592.
10: HEYMANN W, GILKEY C, SALEHAR M, GOLD E. Influence of sodium salicylate and sodium gentisate on proteinuria of lipemic nephrosis. J Lab Clin Med. 1950 May;35(5):737-45. PMID: 15422208.
