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MedKoo Cat#: 575026 | Name: Arpromidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Arpromidine is a biochemical that has been shown to stimulate H2-receptors and may have a therapeutic effect in congestive heart failure (CHF).

Chemical Structure

Arpromidine
CAS#106669-71-0

Theoretical Analysis

MedKoo Cat#: 575026

Name: Arpromidine

CAS#: 106669-71-0

Chemical Formula: C21H25FN6

Exact Mass: 380.2125

Molecular Weight: 380.47

Elemental Analysis: C, 66.29; H, 6.62; F, 4.99; N, 22.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Arpromidine
IUPAC/Chemical Name
(+-)-1-(3-(p-Fluorophenyl)-3-(2-pyridyl)propyl)-3-(3-imidazol-4-ylpropyl)guanidine
InChi Key
KZZIVOLMJPSDEP-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H25FN6/c22-17-8-6-16(7-9-17)19(20-5-1-2-11-25-20)10-13-27-21(23)26-12-3-4-18-14-24-15-28-18/h1-2,5-9,11,14-15,19H,3-4,10,12-13H2,(H,24,28)(H3,23,26,27)
SMILES Code
Fc1ccc(cc1)C(CCNC(=N)NCCCc2cnc[nH]2)c3ccccn3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 380.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1.Felix SB, Buschauer A, Baumann G. Therapeutic value of H2-receptor stimulation in congestive heart failure. Hemodynamic effects of BU-E-76, BU-E-75 and arpromidine (BU-E-50) in comparison to impromidine. Agents Actions Suppl. 1991;33:257-69. doi: 10.1007/978-3-0348-7309-3_16. PMID: 1828932. 2. Xie SX, Schalkhausser F, Ye QZ, Seifert R, Buschauer A. Effects of impromidine- and arpromidine-derived guanidines on recombinant human and guinea pig histamine H1 and H2 receptors. Arch Pharm (Weinheim). 2007 Jan;340(1):9-16. doi: 10.1002/ardp.200600140. PMID: 17206612. 3. Seifert R, Wenzel-Seifert K, Burckstummer T, Pertz HH, Schunack W, Dove S, Buschauer A, Elz S. Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. doi: 10.1124/jpet.103.049619. Epub 2003 Mar 6. PMID: 12626648.