MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 575024 | Name: Arprinocid
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Arprinocid is a coccidiostat (or more likely a coccidiocide, i.e. a drug killing Coccidia parasites)) used in veterinary medicine, frequently eith broiler chickens.

Chemical Structure

Arprinocid
CAS#55779-18-5

Theoretical Analysis

MedKoo Cat#: 575024

Name: Arprinocid

CAS#: 55779-18-5

Chemical Formula: C12H9ClFN5

Exact Mass: 277.0531

Molecular Weight: 277.69

Elemental Analysis: C, 51.90; H, 3.27; Cl, 12.77; F, 6.84; N, 25.22

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 550.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Arpocox; Arprinocid; Arprinocide; MK302; MK-302; MK 302
IUPAC/Chemical Name
9-(2-Chloro-6-fluorophenylmethyl)-9H-purine-6-amine
InChi Key
NAPNOSFRRMHNBJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H9ClFN5/c13-8-2-1-3-9(14)7(8)4-19-6-18-10-11(15)16-5-17-12(10)19/h1-3,5-6H,4H2,(H2,15,16,17)
SMILES Code
Nc1ncnc2c1ncn2Cc3c(F)cccc3Cl
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 277.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wu H, Xiao W, Zhang K, Xue F, Zhang C, Yan M, Wang X, Jiang S. Acute and subchronic toxicity of arprinocid in Sprague-Dawley rats. Regul Toxicol Pharmacol. 2014 Aug;69(3):487-95. doi: 10.1016/j.yrtph.2014.05.017. Epub 2014 May 27. PMID: 24878239. 2: McQuistion TE, McDougald LR. Anticoccidial activity of arprinocid and halofuginone. Vet Parasitol. 1981 Oct;9(1):27-33. doi: 10.1016/0304-4017(81)90004-2. PMID: 7201182. 3: McDougald LR, Johnson JK. Floor pen studies on the anticoccidial efficacy of arprinocid in turkeys. Poult Sci. 1979 Jan;58(1):72-5. doi: 10.3382/ps.0580072. PMID: 471900. 4: Pfefferkorn ER, Eckel ME, McAdams E. Toxoplasma gondii: in vivo and in vitro studies of a mutant resistant to arprinocid-N-oxide. Exp Parasitol. 1988 Apr;65(2):282-9. doi: 10.1016/0014-4894(88)90133-6. PMID: 3350108. 5: Schröder J, Smith CJ, Harvey RG. The anticoccidial efficacy of arprinocid in broiler chickens under floor pen conditions. J S Afr Vet Assoc. 1980 Mar;51(1):59-61. PMID: 7005444. 6: Chapman HD. Field isolates of Eimeria resistant to arprinocid. Vet Parasitol. 1983 Feb;12(1):45-50. doi: 10.1016/0304-4017(83)90086-9. PMID: 6683036. 7: Ball SJ, Pittilo RM, Norton CC, Joyner LP. Morphological effects of arprinocid on developmental stages of Eimeria tenella and E. brunetti. Parasitology. 1985 Aug;91 ( Pt 1):31-43. doi: 10.1017/s0031182000056493. PMID: 4034245. 8: Kilgore RL, Bramel RG, Brokken ES, Olson G, Cox JL, Leaning WH. Efficacy of arprinocid (MK-302) against Eimeria species in broilers. Poult Sci. 1978 Jul;57(4):907-11. doi: 10.3382/ps.0570907. PMID: 674071. 9: Wang CC, Simashkevich PM. A comparative study of the biological activities of arprinocid and arprinocid-1-N-oxide. Mol Biochem Parasitol. 1980 Oct;1(6):335-45. doi: 10.1016/0166-6851(80)90051-1. PMID: 7442720. 10: Wang CC, Simashkevich PM, Stotish RL. Mode of anticoccidial action of arprinocid. Biochem Pharmacol. 1979 Aug 1;28(15):2241-8. doi: 10.1016/0006-2952(79)90685-3. PMID: 497005. 11: Olson G, Tamas T, Smith DA, Weppelman RM, Schleim K, McManus EC. Battery efficacy studies with arprinocid against field strains of Coccidia. Poult Sci. 1978 Sep;57(5):1245-50. doi: 10.3382/ps.0571245. PMID: 724595. 12: Rehg JE, Hancock ML. Effectiveness of arprinocid in the reduction of cryptosporidial activity in immunosuppressed rats. Am J Vet Res. 1990 Oct;51(10):1668-70. PMID: 2240787. 13: Ruff MD, Anderson WI, Reid WM. Effect of the anticoccidial arprinocid on production, sporulation, and infectivity of Eimeria oocysts. J Parasitol. 1978 Apr;64(2):306-11. PMID: 565397. 14: Wang CC, Simashkevich PM, Fan SS. The mechanism of anticoccidial action of arprinocid-1-N-oxide. J Parasitol. 1981 Apr;67(2):137-49. PMID: 7241271. 15: Wang CC, Tolman RL, Simashkevich PM, Stotish RL. Arprinocid, an inhibitor of hypoxanthine-guanine transport. Biochem Pharmacol. 1979 Aug 1;28(15):2249-60. doi: 10.1016/0006-2952(79)90686-5. PMID: 497006. 16: Fink DW, Martin RP, Pivnichny JV, Shim JS. Colorimetric determination of arprinocid in feed. J Assoc Off Anal Chem. 1978 Sep;61(5):1078-82. PMID: 31349. 17: Fink DW. Liquid chromatographic method for determination of arprinocid in feed: collaborative study. J Assoc Off Anal Chem. 1981 Jul;64(4):973-9. PMID: 7275914. 18: Chapman HD. Eimeria tenella: stability of resistance to halofuginone, decoquinate and arprinocid in the chicken. Res Vet Sci. 1986 Jan;40(1):139-40. PMID: 3704320. 19: Maurer K, Decere M, Fried B. Effects of the anthelmintics clorsulon, rafoxanide, mebendazole and arprinocid on Echinostoma caproni in ICR mice. J Helminthol. 1996 Mar;70(1):95-6. doi: 10.1017/s0022149x00015194. PMID: 8960203. 20: Ruff MD, Reid WM, Dykstra DD, Johnson JK. Efficacy of arprinocid against coccidiosis of broilers in battery and floor-pen trials. Avian Dis. 1978 Jan- Mar;22(1):32-41. PMID: 646762.