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MedKoo Cat#: 463344 | Name: Quinclorac
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Quinclorac is a postemergence herbicide, used for the control of broadleaf weeds, especially white clover (Trifolium repens L.) and Veronica filiformis. Quinclorac has been found to pose a high risk for environmental safety.

Chemical Structure

Quinclorac
Quinclorac
CAS#84087-01-4

Theoretical Analysis

MedKoo Cat#: 463344

Name: Quinclorac

CAS#: 84087-01-4

Chemical Formula: C10H5Cl2NO2

Exact Mass: 240.9697

Molecular Weight: 242.06

Elemental Analysis: C, 49.62; H, 2.08; Cl, 29.29; N, 5.79; O, 13.22

Price and Availability

Size Price Availability Quantity
250mg USD 400.00 2 Weeks
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Related CAS #
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Synonym
Quinclorac; Quinclorac tech; Quinclorac-tech;
IUPAC/Chemical Name
3,7-dichloroquinoline-8-carboxylic acid
InChi Key
FFSSWMQPCJRCRV-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H5Cl2NO2/c11-6-3-5-1-2-7(12)8(10(14)15)9(5)13-4-6/h1-4H,(H,14,15)
SMILES Code
OC(c(c(Cl)cc1)c2c1cc(Cl)cn2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
TBD
Shelf Life
>3 years if stored properly
Drug Formulation
TBD
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Quinclorac induces oxidative stress due to free radical generation and changes in the antioxidant defense system.
In vitro activity:
Naegleria fowleri and Balamuthia mandrillaris are pathogenic free-living amoebae that infect the central nervous system with over 95% mortality rates. This study evaluated a range of compounds, including quinclorac, against N. fowleri and B. mandrillaris. All compounds tested showed minimal human cell cytotoxicity as determined by lactate dehydrogenase release. Further research is needed to determine the potential of these repurposed compounds and to determine the intranasal route of delivery to treat these infections. Reference: Antibiotics (Basel). 2022 May 31;11(6):749. https://pubmed.ncbi.nlm.nih.gov/35740156/
In vivo activity:
Tadpoles of Rhinella icterica were collected in a pesticide-free place, acclimated in the laboratory and exposed to three herbicides (atrazine, glyphosate, quinclorac, and their mixtures). Only 2% mortality was observed, but there were significant variations observed for markers of oxidative balance and body condition across experimental groups. The mixture of the three herbicides proved to be most harmful, which points to the need for more restrictive laws for the use of mixed herbicides. Reference: Environ Toxicol Pharmacol. 2023 May 4;100:104145. https://pubmed.ncbi.nlm.nih.gov/37149011/
Solvent mg/mL mM
Solubility
TBD 0.0 0.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 242.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Siddiqui R, Mungroo MR, Anuar TS, Alharbi AM, Alfahemi H, Elmoselhi AB, Khan NA. Antiamoebic Properties of Laboratory and Clinically Used Drugs against Naegleria fowleri and Balamuthia mandrillaris. Antibiotics (Basel). 2022 May 31;11(6):749. doi: 10.3390/antibiotics11060749. PMID: 35740156; PMCID: PMC9220410. 2. Dahabiyeh LA, Bustanji Y, Taha MO. The herbicide quinclorac as potent lipase inhibitor: Discovery via virtual screening and in vitro/in vivo validation. Chem Biol Drug Des. 2019 May;93(5):787-797. doi: 10.1111/cbdd.13463. Epub 2019 Jan 11. PMID: 30570819. 3. Reichert LMM, de Oliveira DR, Papaleo JL, Valgas AAN, Oliveira GT. Impact of commercial formulations of herbicides alone and in mixtures on the antioxidant system and body condition parameters in tadpoles of Rhinella icterica (Spix 1824). Environ Toxicol Pharmacol. 2023 May 4;100:104145. doi: 10.1016/j.etap.2023.104145. Epub ahead of print. PMID: 37149011. 4. Cai X, Chen J, Wang X, Gao H, Xiang B, Dong L. Mefenacet resistance in multiple herbicide-resistant Echinochloa crus-galli L. populations. Pestic Biochem Physiol. 2022 Mar;182:105038. doi: 10.1016/j.pestbp.2022.105038. Epub 2022 Jan 21. PMID: 35249656.
In vitro protocol:
1. Siddiqui R, Mungroo MR, Anuar TS, Alharbi AM, Alfahemi H, Elmoselhi AB, Khan NA. Antiamoebic Properties of Laboratory and Clinically Used Drugs against Naegleria fowleri and Balamuthia mandrillaris. Antibiotics (Basel). 2022 May 31;11(6):749. doi: 10.3390/antibiotics11060749. PMID: 35740156; PMCID: PMC9220410. 2. Dahabiyeh LA, Bustanji Y, Taha MO. The herbicide quinclorac as potent lipase inhibitor: Discovery via virtual screening and in vitro/in vivo validation. Chem Biol Drug Des. 2019 May;93(5):787-797. doi: 10.1111/cbdd.13463. Epub 2019 Jan 11. PMID: 30570819.
In vivo protocol:
1. Reichert LMM, de Oliveira DR, Papaleo JL, Valgas AAN, Oliveira GT. Impact of commercial formulations of herbicides alone and in mixtures on the antioxidant system and body condition parameters in tadpoles of Rhinella icterica (Spix 1824). Environ Toxicol Pharmacol. 2023 May 4;100:104145. doi: 10.1016/j.etap.2023.104145. Epub ahead of print. PMID: 37149011. 2. Cai X, Chen J, Wang X, Gao H, Xiang B, Dong L. Mefenacet resistance in multiple herbicide-resistant Echinochloa crus-galli L. populations. Pestic Biochem Physiol. 2022 Mar;182:105038. doi: 10.1016/j.pestbp.2022.105038. Epub 2022 Jan 21. PMID: 35249656.
1: Munhoz-Garcia GV, Takeshita V, Pinácio CW, Cardoso BC, Vecchia BD, Nalin D, Oliveira ALC, Felix LF, Tornisielo VL. Radiometric approaches with carbon-14-labeled molecules for determining herbicide fate in plant systems. Ecotoxicol Environ Saf. 2024 Sep 7;284:117003. doi: 10.1016/j.ecoenv.2024.117003. Epub ahead of print. PMID: 39244878. 2: Huang Y, Liu Y, Sun M, Lu L, Li X, Jiang K, Li N, Ling S, Wang S. Establishment of highly sensitive lateral flow immunochromatographic strips for quinclorac detection utilizing signal amplification nanoparticles. Food Chem. 2024 Aug 22;463(Pt 1):140960. doi: 10.1016/j.foodchem.2024.140960. Epub ahead of print. PMID: 39236383. 3: Cheng X, Wang A, Cao L, Cao C, Zhao P, Yu M, Zheng L, Huang Q. Efficient delivery of the herbicide quinclorac by nanosuspension for enhancing deposition, uptake and herbicidal activity. Pest Manag Sci. 2024 Sep;80(9):4665-4674. doi: 10.1002/ps.8182. Epub 2024 Jun 17. PMID: 38884421. 4: Zhu S, Liu P, Hong X. Cobalt phthalocyanine (CoPc) anchored on Ti3C2 MXene nanosheets for highly efficient selective catalytic oxidation. Nanoscale Adv. 2024 Apr 26;6(12):3211-3219. doi: 10.1039/d4na00123k. PMID: 38868815; PMCID: PMC11166119. 5: Wang X, Feng S, Luo J, Song S, Lin J, Tian Y, Xu T, Ma J. The Role of FveAFB5 in Auxin-Mediated Responses and Growth in Strawberries. Plants (Basel). 2024 Apr 19;13(8):1142. doi: 10.3390/plants13081142. PMID: 38674551; PMCID: PMC11055006. 6: Porto MAF, Mendes KF, Tornisielo VL, Guiotoku M, de Freitas Souza M, Lins HA, Silva DV. Biochar obtained from eucalyptus, rice hull, and native bamboo as an alternative to decrease mobility of hexazinone, metribuzin, and quinclorac in a tropical soil. Environ Monit Assess. 2024 Apr 4;196(5):423. doi: 10.1007/s10661-024-12589-z. PMID: 38570374. 7: Zhang J, Hu H, Wang J, Lu K, Zhou Y, Zhao L, Peng J. Gold nanoclusters-based fluorescence sensor array for herbicides qualitative and quantitative analysis. Anal Chim Acta. 2024 Apr 15;1298:342380. doi: 10.1016/j.aca.2024.342380. Epub 2024 Feb 21. PMID: 38462337. 8: Serim AT, Patterson EL. Response of conventional sunflower cultivars to drift rates of synthetic auxin herbicides. PeerJ. 2024 Jan 10;12:e16729. doi: 10.7717/peerj.16729. PMID: 38223756; PMCID: PMC10787541. 9: Thompson TS, van den Heever JP, Zarft MJ, Dijanovic S. Determination of quinclorac and quinclorac methyl ester in honey by online SPE-UPLC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2024 Jan;41(1):60-73. doi: 10.1080/19440049.2023.2289131. Epub 2024 Jan 17. PMID: 38048344. 10: Gao H, Yu J, Chen J, Wang H, Liang S, Feng Z, Gu Y, Dong L. Target-Site and Metabolic Resistance Mechanisms to Penoxsulam in Late Watergrass (Echinochloa phyllopogon) in China. J Agric Food Chem. 2023 Nov 22;71(46):17742-17751. doi: 10.1021/acs.jafc.3c05921. Epub 2023 Nov 7. PMID: 37934576. 11: Peng Z, Li S, He H, Wen Y, Huang H, Su L, Yi Z, Peng X, Zhou N. FeS and Fe3O4 Co-modified biochar to build a highly resistant advanced oxidation process system for quinclorac degradation in irrigation water. J Environ Manage. 2023 Dec 15;348:119492. doi: 10.1016/j.jenvman.2023.119492. Epub 2023 Nov 1. PMID: 37922748. 12: Ding C, Ye C, Zhu W, Zeng G, Yao X, Ouyang Y, Rong J, Tao Y, Liu X, Deng Y. Engineered hydrochar from waste reed straw for peroxymonosulfate activation to degrade quinclorac and improve solanaceae plants growth. J Environ Manage. 2023 Dec 1;347:119090. doi: 10.1016/j.jenvman.2023.119090. Epub 2023 Oct 2. PMID: 37793289. 13: Huang CY, Guo L, Song HF, Shen ZJ, Zhang BB, Ma RJ, Yu ML. Safety profile evaluation of different herbicides used on peach rootstock seedlings. Ying Yong Sheng Tai Xue Bao. 2023 Jun;34(6):1583-1591. English. doi: 10.13287/j.1001-9332.202306.010. PMID: 37694421. 14: Shen D, Dai JY, Ji YF. Effect of humus on photodegradation of quinclorac under different fertilization modes. Ying Yong Sheng Tai Xue Bao. 2023 Aug;34(8):2178-2184. English. doi: 10.13287/j.1001-9332.202308.014. PMID: 37681382. 15: Yan Q, Tong J, Li S, Peng Q. Barnyard Grass Stress Triggers Changes in Root Traits and Phytohormone Levels in Allelopathic and Non-Allelopathic Rice. Biology (Basel). 2023 Aug 1;12(8):1074. doi: 10.3390/biology12081074. PMID: 37626960; PMCID: PMC10452299. 16: Zhang L, Wang W, Du Y, Deng Y, Bai T, Ji M. Multiple resistance of Echinochloa phyllopogon to synthetic auxin, ALS-, and ACCase-inhibiting herbicides in Northeast China. Pestic Biochem Physiol. 2023 Jun;193:105450. doi: 10.1016/j.pestbp.2023.105450. Epub 2023 May 4. PMID: 37248019. 17: Reichert LMM, de Oliveira DR, Papaleo JL, Valgas AAN, Oliveira GT. Impact of commercial formulations of herbicides alone and in mixtures on the antioxidant system and body condition parameters in tadpoles of Rhinella icterica (Spix 1824). Environ Toxicol Pharmacol. 2023 Jun;100:104145. doi: 10.1016/j.etap.2023.104145. Epub 2023 May 4. PMID: 37149011. 18: Rigon CAG, Cutti L, Turra GM, Ferreira EZ, Menegaz C, Schaidhauer W, Dayan FE, Gaines TA, Merotto A Jr. Recurrent Selection of Echinochloa crus- galli with a Herbicide Mixture Reduces Progeny Sensitivity. J Agric Food Chem. 2023 May 10;71(18):6871-6881. doi: 10.1021/acs.jafc.3c00920. Epub 2023 Apr 27. PMID: 37104538. 19: Wu L, Wu C, Yang H, Yang J, Wang L, Zhou S. Proteomic Analysis Comparison on the Ecological Adaptability of Quinclorac-Resistant Echinochloa crus- galli. Plants (Basel). 2023 Feb 4;12(4):696. doi: 10.3390/plants12040696. PMID: 36840044; PMCID: PMC9968053. 20: Yuan Y, Chen S, Yao B, Chen A, Peng L, Luo S, Zhou Y. Fe3+-cysteine enhanced persulfate fenton-like process for quinclorac degradation: A wide pH tolerance and reaction mechanism. Environ Res. 2023 May 1;224:115447. doi: 10.1016/j.envres.2023.115447. Epub 2023 Feb 8. PMID: 36758919.

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