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MedKoo Cat#: 463324 | Name: PI3Ki1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PI3Ki1 is a novel potent PI3K inhibitor with a modified omipalisib structure.

Chemical Structure

PI3Ki1
PI3Ki1
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463324

Name: PI3Ki1

CAS#: unknown

Chemical Formula: C27H20F2N4O4S

Exact Mass: 534.1173

Molecular Weight: 534.54

Elemental Analysis: C, 60.67; H, 3.77; F, 7.11; N, 10.48; O, 11.97; S, 6.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PI3Ki1; PI3K i1; PI3K-i1;
IUPAC/Chemical Name
2,4-difluoro-N-(5-(4-(6-(hydroxymethyl)pyridin-3-yl)quinolin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide
InChi Key
RRRSDWCSXDXDCP-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H20F2N4O4S/c1-37-27-25(33-38(35,36)26-7-4-19(28)12-23(26)29)11-18(14-32-27)16-3-6-24-22(10-16)21(8-9-30-24)17-2-5-20(15-34)31-13-17/h2-14,33-34H,15H2,1H3
SMILES Code
O=S(C1=CC=C(F)C=C1F)(NC2=CC(C3=CC=C4N=CC=C(C5=CC=C(CO)N=C5)C4=C3)=CN=C2OC)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 534.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Brandão M, Caparica R, Eiger D, de Azambuja E. Biomarkers of response and resistance to PI3K inhibitors in estrogen receptor-positive breast cancer patients and combination therapies involving PI3K inhibitors. Ann Oncol. 2019 Dec 1;30(Suppl_10):x27-x42. doi: 10.1093/annonc/mdz280. PMID: 31859350; PMCID: PMC6923785.