PAM-2 | CAS#1426293-61-9 | α7 nAChRs modulator

MedKoo Cat#: 463321 | Name: PAM-2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PAM-2 is a novel positive allosteric modulator of α7 nAChRs, decreasing STZ-induced neuropathic pain and chemotherapy-induced neuropathic pain.

Chemical Structure

PAM-2

CAS#1426293-61-9

Theoretical Analysis

MedKoo Cat#: 463321

Name: PAM-2

CAS#: 1426293-61-9

Chemical Formula: C14H13NO2

Exact Mass: 227.0946

Molecular Weight: 227.26

Elemental Analysis: C, 73.99; H, 5.77; N, 6.16; O, 14.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PAM-2; PAM2; PAM 2;

IUPAC/Chemical Name

(E)-3-(furan-2-yl)-N-(p-tolyl)acrylamide

InChi Key

DJMZLFDVBHWQTH-CMDGGOBGSA-N

InChi Code

InChI=1S/C14H13NO2/c1-11-4-6-12(7-5-11)15-14(16)9-8-13-3-2-10-17-13/h2-10H,1H3,(H,15,16)/b9-8+

SMILES Code

O=C(NC1=CC=C(C)C=C1)/C=C/C2=CC=CO2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 227.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Phenis D, Vunck SA, Valentini V, Arias H, Schwarcz R, Bruno JP. Activation of alpha7 nicotinic and NMDA receptors is necessary for performance in a working memory task. Psychopharmacology (Berl). 2020 Jun;237(6):1723-1735. doi: 10.1007/s00213-020-05495-y. Epub 2020 Mar 11. PMID: 32162104; PMCID: PMC7313359. 2: Arias HR, Ghelardini C, Lucarini E, Tae HS, Yousuf A, Marcovich I, Manetti D, Romanelli MN, Elgoyhen AB, Adams DJ, Di Cesare Mannelli L. (E)-3-Furan-2-yl-N-p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation. ACS Chem Neurosci. 2020 Nov 4;11(21):3603-3614. doi: 10.1021/acschemneuro.0c00476. Epub 2020 Oct 19. PMID: 33073974.