nTRD22 is a novel Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43. nTRD22 caused allosteric modulation of the RNA binding domain (RRM) of TDP-43, resulting in decreased binding to RNA in vitro. Moreover, incubation of primary motor neurons with nTRD22 induced a reduction of TDP-43 protein levels, similar to TDP-43 RNA binding-deficient mutants and supporting a disruption of TDP-43 binding to RNA. Finally, nTRD22 mitigated motor impairment in a Drosophila model of amyotrophic lateral sclerosis.
MedKoo Cat#: 463319
Name: nTRD22
CAS#: 1065567-62-5
Chemical Formula: C19H22F3N3O4
Exact Mass: 413.1562
Molecular Weight: 413.40
Elemental Analysis: C, 55.20; H, 5.36; F, 13.79; N, 10.16; O, 15.48
The following data is based on the product molecular weight 413.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
