Synonym
Carbodenafil; Fondenafil; UNII-71OOU63R8M
IUPAC/Chemical Name
5-(2-ethoxy-5-(4-ethylpiperazine-1-carbonyl)phenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
InChi Key
BNQTXDVBJLRWNB-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H32N6O3/c1-5-8-18-20-21(28(4)27-18)23(31)26-22(25-20)17-15-16(9-10-19(17)33-7-3)24(32)30-13-11-29(6-2)12-14-30/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,31)
SMILES Code
CCCc1c2c(C(NC(c3c(OCC)ccc(C(N4CCN(CC4)CC)=O)c3)=N2)=O)n(C)n1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
452.56
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tachikawa H, Nishiyama R, Kosugi Y, Ichikawa-Kaji Y, Uemura N, Moriuchi Y, Moriyasu T, Suzuki T, Inomata A. Variable temperature-nuclear magnetic resonance experiment and high-resolution MS/MSn measurement of hydroxycarbodenafil, and its PDE5 inhibitory activity. J Pharm Biomed Anal. 2024 Aug 15;246:116226. doi: 10.1016/j.jpba.2024.116226. Epub 2024 May 15. PMID: 38788623.
2: Kee CL, Low MY, Ge X. Isolation and characterization of N-phenyl propoxyphenyl carbodenafil from an illegal coffee powder product. J Pharm Biomed Anal. 2022 Feb 5;209:114481. doi: 10.1016/j.jpba.2021.114481. Epub 2021 Nov 23. PMID: 34838347.
3: Mohd Yusop AY, Xiao L, Fu S. Liquid chromatography-high-resolution mass spectrometry analysis of erectile dysfunction drugs and their analogues in food products. Forensic Sci Int. 2021 May;322:110748. doi: 10.1016/j.forsciint.2021.110748. Epub 2021 Mar 4. PMID: 33711768.
4: Kee CL, Ge X, Tran CS, Bui QD, Cheah NP, Low MY. Isolation and characterization of N-hydroxyethyl dithio-desethyl carbodenafil from a health supplement. J Pharm Biomed Anal. 2020 Sep 10;189:113431. doi: 10.1016/j.jpba.2020.113431. Epub 2020 Jun 17. PMID: 32599489.
5: Gu Y, Hu Q, Sun J, Yu H, Pan H, Zhao X, Ji S. Isolation and identification of a new sildenafil analogue, hydroxycarbodenafil, found as an adulterant in a health supplement. J Pharm Biomed Anal. 2020 Jun 5;185:113222. doi: 10.1016/j.jpba.2020.113222. Epub 2020 Feb 29. PMID: 32145539.
6: Kee CL, Low MY, Ge X. Isolation and characterization of a novel dithio- carbodenafil analogue from a health supplement. J Pharm Biomed Anal. 2017 Apr 15;137:132-138. doi: 10.1016/j.jpba.2017.01.010. Epub 2017 Jan 16. PMID: 28113089.
7: Bakota EL, Kelly AT, Walterscheid JP, Phatak DR. A Case Report of Fatal Desmethyl Carbodenafil Toxicity. J Anal Toxicol. 2017 Apr 1;41(3):250-255. doi: 10.1093/jat/bkw128. PMID: 27999095.
