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MedKoo Cat#: 412310 | Name: Elcatonin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Elcatonin is a synthetic S-S bond between 1-7 amino acids displaced by C-C bond; deamino dicarba analog of eel calcitonin; has been given orphan drug approval for intrathecal treatment of intractable pain

Chemical Structure

Elcatonin
Elcatonin
CAS#60731-46-6

Theoretical Analysis

MedKoo Cat#: 412310

Name: Elcatonin

CAS#: 60731-46-6

Chemical Formula: C148H244N42O47

Exact Mass: 3361.7994

Molecular Weight: 3363.83

Elemental Analysis: C, 52.85; H, 7.31; N, 17.49; O, 22.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Elcatonin; HC58; HC 58 HC-58
IUPAC/Chemical Name
1,7-Dicarbacalcitonin (salmon), 1-butanoic acid-26-L-aspartic acid-27-L-valine-29-L-alanine-
InChi Key
JYSJVJJVLNYRKL-UHFFFAOYSA-N
InChi Code
InChI=1S/C148H244N42O47/c1-69(2)52-92(178-142(231)115(75(13)14)185-128(217)87-30-21-20-22-36-113(208)237-67-84(151)122(211)172-98(59-107(154)200)136(225)176-96(56-73(9)10)134(223)182-102(66-192)139(228)188-116(77(16)193)143(232)171-87)123(212)161-63-109(202)165-85(31-23-25-47-149)124(213)173-95(55-72(7)8)133(222)181-101(65-191)138(227)169-89(41-44-105(152)198)126(215)167-91(43-46-111(204)205)127(216)175-94(54-71(5)6)132(221)177-97(58-82-61-158-68-163-82)135(224)166-86(32-24-26-48-150)125(214)174-93(53-70(3)4)131(220)168-90(42-45-106(153)199)130(219)187-118(79(18)195)145(234)180-100(57-81-37-39-83(197)40-38-81)146(235)190-51-29-35-104(190)140(229)170-88(33-27-49-159-148(156)157)129(218)186-117(78(17)194)144(233)179-99(60-112(206)207)137(226)184-114(74(11)12)141(230)162-62-108(201)164-76(15)121(210)160-64-110(203)183-119(80(19)196)147(236)189-50-28-34-103(189)120(155)209/h37-40,61,68-80,84-104,114-119,191-197H,20-36,41-60,62-67,149-151H2,1-19H3,(H2,152,198)(H2,153,199)(H2,154,200)(H2,155,209)(H,158,163)(H,160,210)(H,161,212)(H,162,230)(H,164,201)(H,165,202)(H,166,224)(H,167,215)(H,168,220)(H,169,227)(H,170,229)(H,171,232)(H,172,211)(H,173,213)(H,174,214)(H,175,216)(H,176,225)(H,177,221)(H,178,231)(H,179,233)(H,180,234)(H,181,222)(H,182,223)(H,183,203)(H,184,226)(H,185,217)(H,186,218)(H,187,219)(H,188,228)(H,204,205)(H,206,207)(H4,156,157,159)
SMILES Code
CC(CC(C(NCC(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(N1CCCC1C(NC(C(NC(C(NC(C(NC(C(NCC(NC(C(NCC(NC(C(N2CCCC2C(N)=O)=O)C(O)C)=O)=O)C)=O)=O)C(C)C)=O)CC(O)=O)=O)C(O)C)=O)CCCNC(N)=N)=O)=O)Cc3ccc(O)cc3)=O)C(O)C)=O)CCC(N)=O)=O)CC(C)C)=O)CCCCN)=O)Cc4[nH]cnc4)=O)CC(C)C)=O)CCC(O)=O)=O)CCC(N)=O)=O)CO)=O)CC(C)C)=O)CCCCN)=O)=O)NC(C(C(C)C)NC(C5CCCCCC(OCC(C(NC(C(NC(C(NC(C(NC(C(N5)=O)C(O)C)=O)CO)=O)CC(C)C)=O)CC(N)=O)=O)N)=O)=O)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 3,363.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen WC, Lin EY, Kang YN. Efficacy and safety of elcatonin in postmenopausal women with osteoporosis: a systematic review with network meta-analysis of randomized clinical trials. Osteoporos Int. 2019 Sep;30(9):1723-1732. doi: 10.1007/s00198-019-04997-6. Epub 2019 May 1. PMID: 31041475. 2: Endo N, Fujino K, Doi T, Akai M, Hoshino Y, Nakano T, Iwaya T. Effect of elcatonin versus nonsteroidal anti-inflammatory medications for acute back pain in patients with osteoporotic vertebral fracture: a multiclinic randomized controlled trial. J Bone Miner Metab. 2017 Jul;35(4):375-384. doi: 10.1007/s00774-016-0765-8. Epub 2016 Jul 27. PMID: 27465912. 3: Sugimoto T, Shiraki M, Nakano T, Kishimoto H, Ito M, Fukunaga M, Sone T, Hagino H, Miki T, Nishizawa Y, Akachi S, Nakamura T. A randomized, double-blind, placebo-controlled study of once weekly elcatonin in primary postmenopausal osteoporosis. Curr Med Res Opin. 2019 Mar;35(3):447-454. doi: 10.1080/03007995.2018.1498780. Epub 2018 Aug 7. PMID: 29986611. 4: Fujimoto S, Fujimoto SK. Elcatonin-mediated contractile and relaxant responses in SHR femoral artery. Acta Pharmacol Sin. 2001 Jul;22(7):595-602. PMID: 11749822. 5: Ji Z, Shi C, Huang S, Dang X, Wang K, Lan B. Elcatonin attenuates disuse osteoporosis after fracture fixation of tubular bone in rats. J Orthop Surg Res. 2015 Jul 3;10:103. doi: 10.1186/s13018-015-0246-0. PMID: 26138716; PMCID: PMC4499200. 6: Mori A, Suzawa H, Sakamoto K, Nakahara T, Ishii K. Vasodilator Effects of Elcatonin, a Synthetic Eel Calcitonin, on Retinal Blood Vessels in Rats. Biol Pharm Bull. 2015;38(10):1536-41. doi: 10.1248/bpb.b15-00303. PMID: 26424018. 7: Katae Y, Tanaka S, Sakai A, Nagashima M, Hirasawa H, Nakamura T. Elcatonin injections suppress systemic bone resorption without affecting cortical bone regeneration after drill-hole injuries in mice. J Orthop Res. 2009 Dec;27(12):1652-8. doi: 10.1002/jor.20920. PMID: 19489046. 8: Ikegami S, Kamimura M, Uchiyama S, Nakagawa H, Hashidate H, Takahara K, Takahashi J, Kato H. Anti-nociceptive effects of elcatonin injection for postmenopausal women with back pain: a randomized controlled trial. Open Orthop J. 2010 Mar 4;4:132-6. doi: 10.2174/1874325001004010132. PMID: 20448810; PMCID: PMC2864422. 9: Tanaka S, Yoshida A, Kono S, Oguma T, Hasegawa K, Ito M. Effectiveness of elcatonin for alleviating pain and inhibiting bone resorption in patients with osteoporotic vertebral fractures. J Bone Miner Metab. 2017 Sep;35(5):544-553. doi: 10.1007/s00774-016-0791-6. Epub 2016 Nov 9. PMID: 27830386. 10: Yamane Y, Yamaguchi T, Tsumori M, Yamauchi M, Yano S, Yamamoto M, Honda C, Kinoshita Y, Sugimoto T. Elcatonin is effective for lower back pain and the symptoms of gastroesophageal reflux disease in elderly osteoporotic patients with kyphosis. Geriatr Gerontol Int. 2011 Apr;11(2):215-20. doi: 10.1111/j.1447-0594.2010.00676.x. Epub 2011 Jan 4. PMID: 21199237.