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MedKoo Cat#: 412304 | Name: Carbizocaine (free base)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carbizocaine (free base) is a local anesthetic

Chemical Structure

Carbizocaine (free base)
Carbizocaine (free base)
CAS#76629-87-3(free base)

Theoretical Analysis

MedKoo Cat#: 412304

Name: Carbizocaine (free base)

CAS#: 76629-87-3(free base)

Chemical Formula: C21H36N2O3

Exact Mass: 364.2726

Molecular Weight: 364.53

Elemental Analysis: C, 69.19; H, 9.95; N, 7.68; O, 13.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
76629-87-3 (free base) 68931-03-3 (HCl)
Synonym
Carbizocaine (free base); UNII71PN6ZL7TA; UNII 71PN6ZL7TA; UNII-71PN6ZL7TA
IUPAC/Chemical Name
1-(diethylamino)propan-2-yl (2-(heptyloxy)phenyl)carbamate
InChi Key
PYSAVFUPLJMDHW-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H36N2O3/c1-5-8-9-10-13-16-25-20-15-12-11-14-19(20)22-21(24)26-18(4)17-23(6-2)7-3/h11-12,14-15,18H,5-10,13,16-17H2,1-4H3,(H,22,24)
SMILES Code
CCCCCCCOc1c(NC(OC(CN(CC)CC)C)=O)cccc1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 364.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Stankovičová M, Lašáková A, Medlenová V, Bezáková Z, Cižmárik J. Štúdium lokálnych anestetík: Časť 205* Štúdium stability heptakaíniumchloridu a karbizokaíniumchloridu zrýchleným neizotermickým testom [Studies of local anaesthetics: part 205* studies of stability of heptacainium chloride and carbisocainium chloride using an accelerated non-isothermal test]. Ceska Slov Farm. 2014 Aug;63(4):160-6. Czech. PMID: 25246154. 2: Vegh V, Cizmarik J, Hahnenkamp K. Is there a place for local anesthetics structurally different from classical amid or ester local anesthetics? Curr Opin Anaesthesiol. 2006 Oct;19(5):509-15. doi: 10.1097/01.aco.0000245276.76916.5c. PMID: 16960483. 3: Vegh V, Bukovsky M. Persistent suppression of phagocytosis after prolonged administration of local anesthetics carbisocaine and heptacaine in mouse leukocytes. Pharmazie. 2005 Apr;60(4):317-8. PMID: 15881616. 4: Cizmárik J, Lehotay J, Bednáriková A. Stúdium lokálnych anestetík CLVII. Chromatografické vlastnosti pentakaínu, karbisokaínu, heptakaínu a jeho 3-, a 4-polohových izomérov v RP systéme HPLC [Study of local anesthetics. CLVII. Chromatographic properties of pentacaine, carbisocaine, heptacaine and its 3-, and 4-positional isomers in the RP HPLC system]. Ceska Slov Farm. 2001 Sep;50(5):233-7. Slovak. PMID: 11579689. 5: Ducková K, Kucera J. Liberácia lieciv z impregnovaných krytov na rany [Liberation of drugs from impregnated wound dressings]. Ceska Slov Farm. 1999 Sep;48(5):221-5. Slovak. PMID: 10566242. 6: Ducková K, Kucera J. Topický prípravok na popáleniny a jeho hodnotenie [Topical preparations for burns and their evaluation]. Ceska Slov Farm. 1998 May;47(3):119-23. Slovak. PMID: 9650369. 7: Cizmárik J, Lehotay J, Hromul'aková K, Pokorná M, Lacuska M. HPLC separation of enantiomers of carbisocaine. Study of local anaesthetics, part 138. Pharmazie. 1997 May;52(5):402-3. PMID: 9183793. 8: Stankovicová T, Stolc S, Csöllei J, Benes L. Local anesthetic effect of carbisocaine and its enantiomers. Pharmazie. 1995 Sep;50(9):622-3. PMID: 7480101. 9: Lehotay J, Cizmárik J, Brandsteterová E. Study of local anesthetics. Part 128. HPLC study of the degradation of heptacaine and carbisocaine in urine, human and rabbit serums. Acta Pharm Hung. 1995 May;65(3):95-6. PMID: 7572190. 10: Bednáriková A, Lehotay J, Cizmárik J. Study of local anesthetics. Part 123: HPLC study of pentacaine, heptacaine and carbisocaine. Pharmazie. 1994 Aug;49(8):577-9. PMID: 7938146. 11: Stolc S. Inhibition of ion currents in membrane of sensory neuron by the antiarrhythmic drug BK 129 and selected Ca2+ entry blockers. Gen Physiol Biophys. 1993 Dec;12(6):517-31. Erratum in: Gen Physiol Biophys 1994 Aug;13(4):339. PMID: 8070644. 12: Stankovicová T, Stolc S. Ucinok artikaínu na izolovaný periférny nerv [The effect of articaine on isolated peripheral nerves]. Bratisl Lek Listy. 1993 Jun;94(6):316-20. Slovak. PMID: 8124590. 13: Gallová J, Uhríková D, Balgavý P. Biphasic effect of local anesthetic carbisocaine on fluidity of phosphatidylcholine bilayer. Pharmazie. 1992 Jun;47(6):444-8. PMID: 1329120. 14: Ondrias K, Stasko A, Misík V, Reguli J, Svajdlenka E. Comparison of perturbation effect of propranolol, verapamil, chlorpromazine and carbisocaine on lecithin liposomes and brain total lipid liposomes. An EPR spectroscopy study. Chem Biol Interact. 1991;79(2):197-206. doi: 10.1016/0009-2797(91)90082-i. PMID: 1653117. 15: Kállay Z, Durisová M, Trnovec T, Svoboda V. Effect of gamma-irradiation on disposition of the local anaesthetic, carbisocaine in rabbits. J Pharm Pharmacol. 1990 Dec;42(12):871-3. doi: 10.1111/j.2042-7158.1990.tb07044.x. PMID: 1983152. 16: Bezek S, Trnovec T, Scasnár V, Durisová M, Kukan M, Kállay Z, Laginová V, Svoboda V. Irradiation of the head by 60Co opens the blood-brain barrier for drugs in rats. Experientia. 1990 Oct 15;46(10):1017-20. doi: 10.1007/BF01940660. PMID: 2226715. 17: Racanská E, Svec P, Racanský V. The effect of carbamate local anesthetics on artificial lipid membrane. Pharmazie. 1990 Sep;45(9):684-5. PMID: 2284314. 18: Siekel P. A genotoxicological study of the new local anaesthetic carbamate derivatives carbisocaine, heptacaine and pentacaine. J Appl Toxicol. 1990 Aug;10(4):239-43. doi: 10.1002/jat.2550100403. PMID: 2118149. 19: Ducková K, Kucera J, Koller J. Nový topický prípravok na terapiu popálenín. I. Stúdium niektorých technologických aspektov pripravku [A new topical preparation for the treatment of burns. I. Technical aspects of preparation]. Cesk Farm. 1990 Jul;39(5):199-204. Slovak. PMID: 2208309. 20: Hianik T, Palacková A, Pavelková J. Effects of local anesthetics on mechanical characteristics of lipid bilayers and on the ion transport dynamics. Gen Physiol Biophys. 1990 Jun;9(3):267-80. PMID: 1697553.