MedKoo Cat#: 463263 | Name: GNE-490

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GNE-490 is a highly selective pan-PI3K inhibitor, demonstrating selectivity over mTOR.

Chemical Structure

GNE-490
GNE-490
CAS#1033739-92-2

Theoretical Analysis

MedKoo Cat#: 463263

Name: GNE-490

CAS#: 1033739-92-2

Chemical Formula: C19H24N6O2S

Exact Mass: 400.1681

Molecular Weight: 400.50

Elemental Analysis: C, 56.98; H, 6.04; N, 20.98; O, 7.99; S, 8.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GNE-490; GNE490; GNE 490;
IUPAC/Chemical Name
2-(2-(2-amino-4-methylpyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol
InChi Key
MLCQSTKQERWINQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H24N6O2S/c1-10-13-14(28-15(10)19(3,4)26)17(25-5-7-27-8-6-25)24-16(23-13)12-9-21-18(20)22-11(12)2/h9,26H,5-8H2,1-4H3,(H2,20,21,22)
SMILES Code
NC1=NC=C(C2=NC(N3CCOCC3)=C4C(C(C)=C(C(O)(C)C)S4)=N2)C(C)=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 400.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sampath D, Oeh J, Wyatt SK, Cao TC, Koeppen H, Eastham-Anderson J, Robillard L, Ho CC, Ross J, Zhuang G, Reslan HB, Vitorino P, Barck KH, Ungersma SE, Vernes JM, Caunt M, Van Bruggen N, Ye W, Vijapurkar U, Meng YJ, Ferrara N, Friedman LS, Carano RA. Multimodal microvascular imaging reveals that selective inhibition of class I PI3K is sufficient to induce an antivascular response. Neoplasia. 2013 Jul;15(7):694-711. doi: 10.1593/neo.13470. PMID: 23814482; PMCID: PMC3689233. 2: Sutherlin DP, Sampath D, Berry M, Castanedo G, Chang Z, Chuckowree I, Dotson J, Folkes A, Friedman L, Goldsmith R, Heffron T, Lee L, Lesnick J, Lewis C, Mathieu S, Nonomiya J, Olivero A, Pang J, Prior WW, Salphati L, Sideris S, Tian Q, Tsui V, Wan NC, Wang S, Wiesmann C, Wong S, Zhu BY. Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer. J Med Chem. 2010 Feb 11;53(3):1086-97. doi: 10.1021/jm901284w. PMID: 20050669.