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MedKoo Cat#: 463257 | Name: SiR-Tz

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SiR-Tz is a novel in situ tetrazine ligation reactive silicon-rhodamine dye.

Chemical Structure

SiR-Tz
SiR-Tz
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463257

Name: SiR-Tz

CAS#: unknown

Chemical Formula: C36H35N7O3Si

Exact Mass: 641.2571

Molecular Weight: 641.81

Elemental Analysis: C, 67.37; H, 5.50; N, 15.28; O, 7.48; Si, 4.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SiR-Tz; SiRTz; SiR Tz;
IUPAC/Chemical Name
4-((4-(1,2,4,5-tetrazin-3-yl)benzyl)carbamoyl)-2-(7-(dimethylamino)-3-(dimethyliminio)-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)benzoate
InChi Key
DNWUHPKYNGKAKA-UHFFFAOYSA-N
InChi Code
InChI=1S/C36H35N7O3Si/c1-42(2)25-12-15-28-31(18-25)47(5,6)32-19-26(43(3)4)13-16-29(32)33(28)30-17-24(11-14-27(30)36(45)46)35(44)37-20-22-7-9-23(10-8-22)34-40-38-21-39-41-34/h7-19,21H,20H2,1-6H3,(H-,37,44,45,46)
SMILES Code
O=C([O-])C1=CC=C(C(NCC2=CC=C(C3=NN=CN=N3)C=C2)=O)C=C1C4=C(C=C/5)C([Si](C)(C)C6=CC(N(C)C)=CC=C46)=CC5=[N+](C)/C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 641.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gupta A, Rivera-Molina F, Xi Z, Toomre D, Schepartz A. Endosome motility defects revealed at super-resolution in live cells using HIDE probes. Nat Chem Biol. 2020 Apr;16(4):408-414. doi: 10.1038/s41589-020-0479-z. Epub 2020 Feb 24. PMID: 32094922; PMCID: PMC7176048. 2: Thompson AD, Omar MH, Rivera-Molina F, Xi Z, Koleske AJ, Toomre DK, Schepartz A. Long-Term Live-Cell STED Nanoscopy of Primary and Cultured Cells with the Plasma Membrane HIDE Probe DiI-SiR. Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10408-10412. doi: 10.1002/anie.201704783. Epub 2017 Jul 24. PMID: 28679029; PMCID: PMC5576494. 3: Erdmann RS, Takakura H, Thompson AD, Rivera-Molina F, Allgeyer ES, Bewersdorf J, Toomre D, Schepartz A. Super-resolution imaging of the Golgi in live cells with a bioorthogonal ceramide probe. Angew Chem Int Ed Engl. 2014 Sep 15;53(38):10242-6. doi: 10.1002/anie.201403349. Epub 2014 Jul 31. PMID: 25081303; PMCID: PMC4593319. 4: Erdmann RS, Toomre D, Schepartz A. STED Imaging of Golgi Dynamics with Cer- SiR: A Two-Component, Photostable, High-Density Lipid Probe for Live Cells. Methods Mol Biol. 2017;1663:65-78. doi: 10.1007/978-1-4939-7265-4_6. PMID: 28924659; PMCID: PMC6146391.