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MedKoo Cat#: 463254 | Name: EMI1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EMI1 is a novel EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S activating mutant inhibitor.

Chemical Structure

EMI1
EMI1
CAS#35773-42-3

Theoretical Analysis

MedKoo Cat#: 463254

Name: EMI1

CAS#: 35773-42-3

Chemical Formula: C20H18N2O3

Exact Mass: 334.1317

Molecular Weight: 334.38

Elemental Analysis: C, 71.84; H, 5.43; N, 8.38; O, 14.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
EMI1; EMI 1; EMI-1; EGFR MaMTH Inhibitor 1;
IUPAC/Chemical Name
3-(benzo[d]oxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one
InChi Key
UJOQSHCJYVRZKJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H18N2O3/c1-3-22(4-2)14-10-9-13-11-15(20(23)25-18(13)12-14)19-21-16-7-5-6-8-17(16)24-19/h5-12H,3-4H2,1-2H3
SMILES Code
O=C1C(C2=NC3=CC=CC=C3O2)=CC4=C(O1)C=C(N(CC)CC)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 334.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu YF, Shen YJ, Yang Y, Chao L, Yang F. [Early Mitotic Inhibitor 1 Regulates DNA Re-replication Mediated by Human Papillomavirus Subtype 16 E7 in Response to DNA Damage]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2020 Aug 30;42(4):485-490. Chinese. doi: 10.3881/j.issn.1000-503X.12778. PMID: 32895100. 2: Chen Z, Li C. Quantifying the Landscape and Transition Paths for Proliferation-Quiescence Fate Decisions. J Clin Med. 2020 Aug 10;9(8):2582. doi: 10.3390/jcm9082582. PMID: 32784979; PMCID: PMC7466041. 3: Cai T, Zhou J, Zeng Y, Du W, Zhang Y, Liu T, Fu Y, Huang JA, Qian Q, Zhu J, Ling C, Liu Z. EVI5 is an oncogene that regulates the proliferation and metastasis of NSCLC cells. J Exp Clin Cancer Res. 2020 May 11;39(1):84. doi: 10.1186/s13046-020-01585-z. PMID: 32393392; PMCID: PMC7212589. 4: Wang M, Yang C, Liu X, Zheng J, Xue Y, Ruan X, Shen S, Wang D, Li Z, Cai H, Liu Y. An upstream open reading frame regulates vasculogenic mimicry of glioma via ZNRD1-AS1/miR-499a-5p/ELF1/EMI1 pathway. J Cell Mol Med. 2020 Jun;24(11):6120-6136. doi: 10.1111/jcmm.15217. Epub 2020 May 5. PMID: 32368853; PMCID: PMC7294115. 5: Subramanian GN, Greaney J, Wei Z, Becherel O, Lavin M, Homer HA. Oocytes mount a noncanonical DNA damage response involving APC-Cdh1-mediated proteolysis. J Cell Biol. 2020 Apr 6;219(4):e201907213. doi: 10.1083/jcb.201907213. PMID: 32328643; PMCID: PMC7147104. 6: Hou W, Kaczorowski A, Lantwin P, Kippenberger M, Schütz V, Franke D, Dieffenbacher SC, Hohenfellner M, Duensing S. Microenvironment-Derived FGF-2 Stimulates Renal Cell Carcinoma Cell Proliferation through Modulation of p27Kip1: Implications for Spatial Niche Formation and Functional Intratumoral Heterogeneity. Pathobiology. 2020;87(2):114-124. doi: 10.1159/000506709. Epub 2020 Mar 31. PMID: 32229735; PMCID: PMC7265770. 7: Mao CG, Zhou XC, Jiang YD, Wan LJ, Tao ZZ, Guo J. The Evi5 oncogene promotes laryngeal cancer cells proliferation by stabilizing c-Myc protein. Cancer Cell Int. 2020 Feb 7;20:44. doi: 10.1186/s12935-020-1127-0. PMID: 32047362; PMCID: PMC7006165. 8: McHugh A, Fernandes K, Chinner N, Ibrahim AFM, Garg AK, Boag G, Hepburn LA, Proby CM, Leigh IM, Saville MK. The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma. J Invest Dermatol. 2020 Jun;140(6):1154-1165.e5. doi: 10.1016/j.jid.2019.09.024. Epub 2019 Nov 6. PMID: 31705877; PMCID: PMC7254059. 9: Yang M, Jin Y, Fan S, Liang X, Jia J, Tan Z, Huang T, Li Y, Ma T, Li M. Inhibition of neddylation causes meiotic arrest in mouse oocyte. Cell Cycle. 2019 Jun;18(11):1254-1267. doi: 10.1080/15384101.2019.1617453. Epub 2019 May 21. PMID: 31111756; PMCID: PMC6592254. 10: De K, Grubb TM, Zalenski AA, Pfaff KE, Pal D, Majumder S, Summers MK, Venere M. Hyperphosphorylation of CDH1 in Glioblastoma Cancer Stem Cells Attenuates APC/CCDH1 Activity and Pharmacologic Inhibition of APC/CCDH1/CDC20 Compromises Viability. Mol Cancer Res. 2019 Jul;17(7):1519-1530. doi: 10.1158/1541-7786.MCR-18-1361. Epub 2019 Apr 29. PMID: 31036696; PMCID: PMC7271747. 11: Adamovich AI, Toland AE, Parvin JD. F-Box Protein-Mediated Resistance to PARP Inhibitor Therapy. Mol Cell. 2019 Jan 17;73(2):195-196. doi: 10.1016/j.molcel.2018.12.019. PMID: 30658107. 12: Marzio A, Puccini J, Kwon Y, Maverakis NK, Arbini A, Sung P, Bar-Sagi D, Pagano M. The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers. Mol Cell. 2019 Jan 17;73(2):224-237.e6. doi: 10.1016/j.molcel.2018.11.003. Epub 2018 Dec 13. PMID: 30554948; PMCID: PMC6995265. 13: Cappell SD, Mark KG, Garbett D, Pack LR, Rape M, Meyer T. EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle. Nature. 2018 Jun;558(7709):313-317. doi: 10.1038/s41586-018-0199-7. Epub 2018 Jun 6. PMID: 29875408; PMCID: PMC6035873. 14: Pandey N, Vinod PK. Mathematical modelling of reversible transition between quiescence and proliferation. PLoS One. 2018 Jun 1;13(6):e0198420. doi: 10.1371/journal.pone.0198420. PMID: 29856829; PMCID: PMC5983510. 15: Xu XL, Li Z, Liu A, Fan X, Hu DN, Qi DL, Chitty DW, Jia R, Qui J, Wang JQ, Sharaf J, Zou J, Weiss R, Huang H, Joseph WJ, Ng L, Rosen R, Shen B, Reid MW, Forrest D, Abramson DH, Singer S, Cobrinik D, Jhanwar SC. SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells. Cancer Res. 2017 Dec 15;77(24):6838-6850. doi: 10.1158/0008-5472.CAN-16-3299. Epub 2017 Sep 28. PMID: 28972075; PMCID: PMC5732859. 16: Schoonen PM, Talens F, Stok C, Gogola E, Heijink AM, Bouwman P, Foijer F, Tarsounas M, Blatter S, Jonkers J, Rottenberg S, van Vugt MATM. Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells. Nat Commun. 2017 Jul 17;8:15981. doi: 10.1038/ncomms15981. PMID: 28714471; PMCID: PMC5520019. 17: Hung CM, Lin YC, Liu LC, Kuo SC, Ho CT, Way TD. CWF-145, a novel synthetic quinolone derivative exerts potent antimitotic activity against human prostate cancer: Rapamycin enhances antimitotic drug-induced apoptosis through the inhibition of Akt/mTOR pathway. Chem Biol Interact. 2016 Dec 25;260:1-12. doi: 10.1016/j.cbi.2016.10.014. Epub 2016 Oct 18. PMID: 27769712. 18: Ricolo D, Deligiannaki M, Casanova J, Araújo SJ. Centrosome Amplification Increases Single-Cell Branching in Post-mitotic Cells. Curr Biol. 2016 Oct 24;26(20):2805-2813. doi: 10.1016/j.cub.2016.08.020. Epub 2016 Sep 29. PMID: 27693136. 19: Fujioka YA, Onuma A, Fujii W, Sugiura K, Naito K. Analyses of EMI functions on meiotic maturation of porcine oocytes. Mol Reprod Dev. 2016 Nov;83(11):983-992. doi: 10.1002/mrd.22738. Epub 2016 Oct 7. PMID: 27649288. 20: Feringa FM, Krenning L, Koch A, van den Berg J, van den Broek B, Jalink K, Medema RH. Hypersensitivity to DNA damage in antephase as a safeguard for genome stability. Nat Commun. 2016 Aug 26;7:12618. doi: 10.1038/ncomms12618. PMID: 27561326; PMCID: PMC5007458.

View History

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