MedKoo Cat#: 463248 | Name: AS408

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AS408 is a novel allosteric modulator of the β2-adrenergic receptor (β2AR), binding to the membrane-facing surface of transmembrane segments 3 and 5.

Chemical Structure

AS408
AS408
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463248

Name: AS408

CAS#: unknown

Chemical Formula: C14H11BrN4

Exact Mass: 314.0167

Molecular Weight: 315.17

Elemental Analysis: C, 53.35; H, 3.52; Br, 25.35; N, 17.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AS408; AS 408; AS-408;
IUPAC/Chemical Name
6-bromo-N2-phenylquinazoline-2,4-diamine
InChi Key
MPGNABXYXOGUGH-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H11BrN4/c15-9-6-7-12-11(8-9)13(16)19-14(18-12)17-10-4-2-1-3-5-10/h1-8H,(H3,16,17,18,19)
SMILES Code
NC1=C2C=C(Br)C=CC2=NC(NC3=CC=CC=C3)=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 315.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu X, Kaindl J, Korczynska M, Stößel A, Dengler D, Stanek M, Hübner H, Clark MJ, Mahoney J, Matt RA, Xu X, Hirata K, Shoichet BK, Sunahara RK, Kobilka BK, Gmeiner P. An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor. Nat Chem Biol. 2020 Jul;16(7):749-755. doi: 10.1038/s41589-020-0549-2. Epub 2020 Jun 1. PMID: 32483378.