BRD3731 is a selective GSK3β inhibitor, with IC50s of 15 nM and 215 nM for GSK3β and GSK3α, respectively. It displays 14-fold selectivity for GSK3β. BRD3731 displays reduced potency towards the GSK3β (D133E), with an IC50 = 53 nM compared to GSK3β (wt) (cf. IC50 = 15 nM). Moreover, BRD3731 inhibits GSK3β with a Kd of 3.3 μM in cellular context. In addition, BRD3731 is a GSK3β- selective inhibitor from patent US20160375006A1, compound example 272.
MedKoo Cat#: 555879
Name: BRD3731
CAS#: 2056262-08-7
Chemical Formula: C24H31N3O
Exact Mass: 377.2467
Molecular Weight: 377.53
Elemental Analysis: C, 76.35; H, 8.28; N, 11.13; O, 4.24
The following data is based on the product molecular weight 377.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
