MedKoo Cat#: 412266 | Name: Canrenoic Acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Canrenoic Acid is a synthetic pregnadiene derivative with anti-aldosterone activity.

Chemical Structure

Canrenoic Acid
Canrenoic Acid
CAS#4138-96-9

Theoretical Analysis

MedKoo Cat#: 412266

Name: Canrenoic Acid

CAS#: 4138-96-9

Chemical Formula: C22H30O4

Exact Mass: 358.2144

Molecular Weight: 358.48

Elemental Analysis: C, 73.71; H, 8.44; O, 17.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Canrenoic Acid; EINECS223-963-0; EINECS-223-963-0; EINECS 223-963-0
IUPAC/Chemical Name
3-((8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)propanoic acid
InChi Key
PBKZPPIHUVSDNM-WNHSNXHDSA-N
InChi Code
InChI=1S/C22H30O4/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25)/t16-,17+,18+,20+,21+,22-/m1/s1
SMILES Code
C[C@]12CCC(C=C1C=C[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@]4(CCC(O)=O)O)C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Canrenoic acid is a synthetic steroidal antimineralocorticoid which was never marketed.

Preparing Stock Solutions

The following data is based on the product molecular weight 358.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Potassium canrenoate treatment in paediatric patients: a population pharmacokinetic study using novel dried blood spot sampling. J Hypertens. 2013 Sep;31(9):1901-8. doi: 10.1097/HJH.0b013e3283626994. PMID: 23846862. 18: Feng X, Reini SA, Richards E, Wood CE, Keller-Wood M. Cortisol stimulates proliferation and apoptosis in the late gestation fetal heart: differential effects of mineralocorticoid and glucocorticoid receptors. Am J Physiol Regul Integr Comp Physiol. 2013 Aug 15;305(4):R343-50. doi: 10.1152/ajpregu.00112.2013. Epub 2013 Jun 19. PMID: 23785077; PMCID: PMC3833392. 19: Rademaker MT, Charles CJ, Nicholls MG, Richards AM. Interactions of enhanced urocortin 2 and mineralocorticoid receptor antagonism in experimental heart failure. Circ Heart Fail. 2013 Jul;6(4):825-32. doi: 10.1161/CIRCHEARTFAILURE.112.000205. Epub 2013 Jun 10. PMID: 23753530. 20: Rossi R, Crupi N, Coppi F, Monopoli D, Sgura F. 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