IUPAC/Chemical Name
(5S,11R)-13,16-dimethyl-1,7-bis((3aR,8aR)-1-methyl-2,3,8,8a-tetrahydropyrrolo[2,3-b]indol-3a(1H)-yl)-5,6,11,12-tetrahydro-5,10b:11,4b-bis(epiminoethano)dibenzo[c,h][2,6]naphthyridine
InChi Key
HEDIOFZXUDVGEU-WATQSORBSA-N
InChi Code
InChI=1S/C44H50N8/c1-26-25-45-37-43-21-24-52(4)40(49-35-29(13-9-15-31(35)43)41-19-22-50(2)38(41)46-33-17-7-5-11-27(33)41)44(26,43)32-16-10-14-30(36(32)48-37)42-20-23-51(3)39(42)47-34-18-8-6-12-28(34)42/h5-18,26,37-40,45-49H,19-25H2,1-4H3/t26?,37-,38+,39+,40+,41+,42+,43?,44?/m0/s1
SMILES Code
CC1CN[C@H]2Nc3c(C14[C@@H]5Nc6c(C24CCN5C)cccc6[C@]78CCN([C@H]7Nc9c8cccc9)C)cccc3[C@]%10%11CCN([C@H]%10Nc%12c%11cccc%12)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
690.94
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Juster RP, Sindi S, Marin MF, Perna A, Hashemi A, Pruessner JC, Lupien SJ. A clinical allostatic load index is associated with burnout symptoms and hypocortisolemic profiles in healthy workers. Psychoneuroendocrinology. 2011 Jul;36(6):797-805. doi: 10.1016/j.psyneuen.2010.11.001. Epub 2010 Dec 3. PMID: 21129851.
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4: Rasolonjanahary R, Sévenet T, Guéritte Voegelein F, Kordon C. Psycholeine, a natural alkaloid extracted from Psychotria oleoides, acts as a weak antagonist of somatostatin. Eur J Pharmacol. 1995 Oct 4;285(1):19-23. doi: 10.1016/0014-2999(95)00345-l. PMID: 8846807.
5: Guéritte-Voegelein F, Sévenet T, Pusset J, Adeline MT, Gillet B, Beloeil JC, Guénard D, Potier P, Rasolonjanahary R, Kordon C. Alkaloids from Psychotria oleoides with activity on growth hormone release. J Nat Prod. 1992 Jul;55(7):923-30. doi: 10.1021/np50085a012. PMID: 1402957.
6: Sévenet T. Looking for new drugs: what criteria? J Ethnopharmacol. 1991 Apr;32(1-3):83-90. doi: 10.1016/0378-8741(91)90106-n. PMID: 1881171.
