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MedKoo Cat#: 412221 | Name: Ceruletide diethylamine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ceruletide diethylamine is a specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.

Chemical Structure

Ceruletide diethylamine
CAS#71247-25-1

Theoretical Analysis

MedKoo Cat#: 412221

Name: Ceruletide diethylamine

CAS#: 71247-25-1

Chemical Formula: C62H86N14O21S2

Exact Mass: 1426.5533

Molecular Weight: 1427.57

Elemental Analysis: C, 52.16; H, 6.07; N, 13.74; O, 23.54; S, 4.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ceruletide diethylamine; 883-S; EINECS 275-298-0; Cerulen
IUPAC/Chemical Name
5-Oxo-L-prolyl-L-glutaminyl-L-alpha-aspartyl-O-sulfo-L-tyrosyl-L-threonylglycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide compound with N-ethylethanamine
InChi Key
YZEJAGFJEOMCNF-RTEYGVOXSA-N
InChi Code
InChI=1S/C58H75N13O21S2.C4H11N/c1-29(92-94(89,90)91)49(71-57(87)39(22-31-14-16-43(72)44(73)23-31)68-56(86)42(26-48(78)79)69-52(82)36(15-17-45(59)74)65-51(81)35-13-8-19-61-35)58(88)63-28-46(75)64-40(24-32-27-62-34-12-7-6-11-33(32)34)54(84)66-37(18-20-93-2)53(83)70-41(25-47(76)77)55(85)67-38(50(60)80)21-30-9-4-3-5-10-30;1-3-5-4-2/h3-7,9-12,14,16,27,29,35-42,49,61-62,72H,8,13,15,17-26,28H2,1-2H3,(H2,59,74)(H2,60,80)(H,63,88)(H,64,75)(H,65,81)(H,66,84)(H,67,85)(H,68,86)(H,69,82)(H,70,83)(H,71,87)(H,76,77)(H,78,79)(H,89,90,91);5H,3-4H2,1-2H3/t29-,35+,36+,37+,38+,39+,40+,41+,42+,49+;/m1./s1
SMILES Code
O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CNC([C@H]([C@H](OS(=O)(O)=O)C)NC([C@H](CC4=CC=C(C(C4)=O)O)NC([C@H](CC(O)=O)NC([C@H](CCC(N)=O)NC([C@H]5NCCC5)=O)=O)=O)=O)=O)=O)=O)=O)=O.CCNCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,427.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sugiyama Y, Kato S, Abe M, Mitsufuji S, Takeuchi K. Different effects of dexamethasone and the nitric oxide synthase inhibitor L-NAME on caerulein- induced rat acute pancreatitis, depending on the severity. Inflammopharmacology. 2005;13(1-3):291-301. doi: 10.1163/156856005774423728. PMID: 16259748. 2: Saito A. Effects of food, ceruletide and ranitidine on the pharmacokinetics of the oral cephalosporin S-1108 in humans. Chemotherapy. 1993 Nov- Dec;39(6):374-85. doi: 10.1159/000238980. PMID: 8222863. 3: Shimotake T, Iwai N, Yanagihara J, Tokiwa K, Fushiki S. Biliary tract complications in patients with hypoganglionosis and chronic idiopathic intestinal pseudoobstruction syndrome. J Pediatr Surg. 1993 Feb;28(2):189-92. doi: 10.1016/s0022-3468(05)80272-6. PMID: 8437078. 4: Kihara T, Ikeda M, Matsushita A. Ceruletide, a cholecystokinin-related peptide, attenuates haloperidol-induced increase in dopamine release from the rat striatum: an in vivo microdialysis study. Brain Res. 1990 Jun 11;519(1-2):44-9. doi: 10.1016/0006-8993(90)90058-j. PMID: 2397417. 5: Itoh H, Murase K, Hamamoto K. Reflux sign in cholescintigraphy after administration of a gallbladder contracting agent. J Nucl Med. 1989 Jul;30(7):1192-7. PMID: 2738700. 6: Itoh H, Shimono R, Murase K, Koito H, Iio A, Hamamoto K. [Diagnostic value of the reflux sign in cholescintigraphy after administration of a gallbladder contracting agent--a comparison with X-ray cholangiography]. Nihon Igaku Hoshasen Gakkai Zasshi. 1989 Jan 25;49(1):66-72. Japanese. PMID: 2734083. 7: Simko V, Michael S. Bile acid levels in diagnosing mild liver disease. Fasting and postcholecystokinetic values. Arch Intern Med. 1986 Apr;146(4):695-7. PMID: 3516097. 8: Krishnamurthy GT, Turner FE, Mangham D, Bobba VV, White SA, Langrell K. Ceruletide intravenous dose-response study by a simplified scintigraphic technique. AJR Am J Roentgenol. 1985 Apr;144(4):733-7. doi: 10.2214/ajr.144.4.733. PMID: 3872030. 9: Hommer DW, Pickar D, Roy A, Ninan P, Boronow J, Paul SM. The effects of ceruletide in schizophrenia. Arch Gen Psychiatry. 1984 Jun;41(6):617-9. doi: 10.1001/archpsyc.1984.01790170091010. PMID: 6329121. 10: Nahum H, Witz MO, Bernades P. Intérêt du cérulétide en cholécystographie orale [The value of ceruletide in oral cholecystography]. J Radiol. 1984 Feb;65(2):105-6. French. PMID: 6716333. 11: Renner IG, Wisner JR Jr, Rinderknecht H. Protective effects of exogenous secretin on ceruletide-induced acute pancreatitis in the rat. J Clin Invest. 1983 Sep;72(3):1081-92. doi: 10.1172/JCI111033. PMID: 6193140; PMCID: PMC1129276. 12: Moroji T, Matsushita K. [Antipsychotic action of ceruletide diethylamine (caerulein), a substance resembling CCK-8]. Seishin Shinkeigaku Zasshi. 1983;85(11):802-4. Japanese. PMID: 6677915. 13: Kemmann E, Jones JR. Clear breast discharge. JAMA. 1982 Sep 10;248(10):1180. doi: 10.1001/jama.1982.03330100020017. PMID: 7202054. 14: Hosaka Y. [Exocrine secretion of pancreas after the administration of ceruletide diethylamine, cholecystokinin-pancreozymin and tetragastrin in rats (author's transl)]. Nihon Ika Daigaku Zasshi. 1981 Jun;48(3):370-6. Japanese. doi: 10.1272/jnms1923.48.370. PMID: 7298821.