Synonym
Z433927330; Z-433927330; Z 433927330;
IUPAC/Chemical Name
ethyl 4-(3-(4-(1H-pyrazol-1-yl)benzyl)ureido)benzoate
InChi Key
KQUKHINHCUELQL-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H20N4O3/c1-2-27-19(25)16-6-8-17(9-7-16)23-20(26)21-14-15-4-10-18(11-5-15)24-13-3-12-22-24/h3-13H,2,14H2,1H3,(H2,21,23,26)
SMILES Code
O=C(OCC)C1=CC=C(NC(NCC2=CC=C(N3N=CC=C3)C=C2)=O)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
The aquaglyceroporins are a subfamily of aquaporins that conduct both water and glycerol. Aquaporin-3 (AQP3) has an important physiological function in renal water reabsorption, and AQP3-mediated hydrogen peroxide (H2O2) permeability can enhance cytokine signaling in several cell types. The related aquaglyceroporin AQP7 is required for dendritic cell chemokine responses and antigen uptake. Selective small-molecule inhibitors are desirable tools for investigating the biological and pathological roles of these and other AQP isoforms.
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
364.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Charlestin V, Tan E, Arias-Matus CE, Wu J, Miranda-Vergara MC, Lee M, Wang M, Nannapaneni DT, Tennakoon P, Blagg BSJ, Ashfeld BL, Kaliney W, Li J, Littlepage LE. Evaluation of the Mammalian Aquaporin Inhibitors Auphen and Z433927330 in Treating Breast Cancer. Cancers (Basel). 2024 Jul 30;16(15):2714. doi: 10.3390/cancers16152714. PMID: 39123442; PMCID: PMC11311482.
2: Huang P, Åbacka H, Wilson CJ, Wind ML, Rűtzler M, Hagström-Andersson A, Gourdon P, de Groot BL, Venskutonytė R, Lindkvist-Petersson K. Molecular basis for human aquaporin inhibition. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2319682121. doi: 10.1073/pnas.2319682121. Epub 2024 Feb 6. PMID: 38319972; PMCID: PMC10873552.
3: Ribeiro JC, Bernardino RL, Gonçalves A, Barros A, Calamita G, Alves MG, Oliveira PF. Aquaporin-7-Mediated Glycerol Permeability Is Linked to Human Sperm Motility in Asthenozoospermia and during Sperm Capacitation. Cells. 2023 Aug 5;12(15):2003. doi: 10.3390/cells12152003. PMID: 37566082; PMCID: PMC10416866.
4: Sonntag Y, Gena P, Maggio A, Singh T, Artner I, Oklinski MK, Johanson U, Kjellbom P, Nieland JD, Nielsen S, Calamita G, Rützler M. Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem. 2019 May 3;294(18):7377-7387. doi: 10.1074/jbc.RA118.006083. Epub 2019 Mar 11. PMID: 30862673; PMCID: PMC6509502.
