MedKoo Cat#: 574947 | Name: ZM-449829
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZM-449829 is an inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site and inhibits STAT-5 phosphorylation and T cell proliferation.

Chemical Structure

ZM-449829
ZM-449829
CAS#4452-06-6

Theoretical Analysis

MedKoo Cat#: 574947

Name: ZM-449829

CAS#: 4452-06-6

Chemical Formula: C13H10O

Exact Mass: 182.0732

Molecular Weight: 182.22

Elemental Analysis: C, 85.69; H, 5.53; O, 8.78

Price and Availability

Size Price Availability Quantity
5mg USD 400.00 2 Weeks
10mg USD 750.00 2 Weeks
25mg USD 1,250.00 2 Weeks
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Related CAS #
No Data
Synonym
ZM-449829; ZM 449829; ZM449829
IUPAC/Chemical Name
1-(2-Naphthalenyl)-2-propen-1-one
InChi Key
FOTCGZPFSUWZBN-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2
SMILES Code
C=CC(C1=CC=C2C=CC=CC2=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 182.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Brown et al (2000) Naphthyl ketones: a new class of janus kinase 3 inhibitors Bioorg.Med.Chem.Lett. 10 575 PMID: 10741557 2. Orange et al (2011) IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. J.Clin.Invest. 121 1535 PMID: 21383498