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MedKoo Cat#: 574943 | Name: YM-750

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YM-750 is an Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor that exhibits hypocholesterolaemic and antiatherosclerotic activity in vivo.

Chemical Structure

YM-750
YM-750
CAS#138046-43-2

Theoretical Analysis

MedKoo Cat#: 574943

Name: YM-750

CAS#: 138046-43-2

Chemical Formula: C31H36N2O

Exact Mass: 452.2828

Molecular Weight: 452.64

Elemental Analysis: C, 82.26; H, 8.02; N, 6.19; O, 3.53

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
YM 750; YM750; YM-750
IUPAC/Chemical Name
N-Cycloheptyl-N-(9H-fluoren-2-ylmethyl)-N'-(2,4,6-trimethylphenyl)urea
InChi Key
FMLJREWZCZHGGW-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H36N2O/c1-21-16-22(2)30(23(3)17-21)32-31(34)33(27-11-6-4-5-7-12-27)20-24-14-15-29-26(18-24)19-25-10-8-9-13-28(25)29/h8-10,13-18,27H,4-7,11-12,19-20H2,1-3H3,(H,32,34)
SMILES Code
O=C(NC1=C(C)C=C(C)C=C1C)N(C2CCCCCC2)CC3=CC(CC4=C5C=CC=C4)=C5C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 452.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Nagata et al (1995) N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]-(2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. Biochem.Pharmacol. 49 643 PMID: 7887979 2. Kamiya et al (2000) Bioavailable acyl-CoA: cholesterol acyltransferase inhibitor with anti-peroxidative activity: synthesis and biological activity of novel indolinyl amide and urea derivatives. Chem.Pharm.Bull. 48 817 PMID: 10866142 3. Miike et al (2008) Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell dervied foam cells. Life Sci. 82 79 PMID: 18037448