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MedKoo Cat#: 574942 | Name: YM-244769 dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YM-244769 dihydrochloride is a Na+/Ca2+ exchange inhibitor (reverse mode). It can also act as a neuroprotectant against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.

Chemical Structure

YM-244769 dihydrochloride
YM-244769 dihydrochloride
CAS#837424-39-2

Theoretical Analysis

MedKoo Cat#: 574942

Name: YM-244769 dihydrochloride

CAS#: 837424-39-2

Chemical Formula: C26H24Cl2FN3O3

Exact Mass: 515.1179

Molecular Weight: 516.39

Elemental Analysis: C, 60.47; H, 4.68; Cl, 13.73; F, 3.68; N, 8.14; O, 9.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
YM-244769 dihydrochloride; YM-244769 2HCl; YM 244769; YM244769
IUPAC/Chemical Name
N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide Dihydrochloride
InChi Key
OCKIUNLKEPKCRE-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H22FN3O3.2ClH/c27-21-5-1-4-19(13-21)17-32-23-8-10-24(11-9-23)33-25-12-7-20(16-29-25)26(31)30-15-18-3-2-6-22(28)14-18;;/h1-14,16H,15,17,28H2,(H,30,31);2*1H
SMILES Code
O=C(C1=CC=C(OC2=CC=C(OCC3=CC=CC(F)=C3)C=C2)N=C1)NCC4=CC=CC(N)=C4.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 516.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Yamashita K, Watanabe Y, Kita S, Iwamoto T, Kimura J. Inhibitory effect of YM-244769, a novel Na+/Ca2+ exchanger inhibitor on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol. 2016 Nov;389(11):1205-1214. doi: 10.1007/s00210-016-1282-y. Epub 2016 Aug 1. PMID: 27480939. 2. Iwamoto T, Kita S. YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol Pharmacol. 2006 Dec;70(6):2075-83. doi: 10.1124/mol.106.028464. Epub 2006 Sep 14. PMID: 16973719. 3. Hu HJ, Wang SS, Wang YX, Liu Y, Feng XM, Shen Y, Zhu L, Chen HZ, Song M. Blockade of the forward Na+ /Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+ -mediated cell death. Br J Pharmacol. 2019 Aug;176(15):2691-2707. doi: 10.1111/bph.14692. Epub 2019 Jun 17. PMID: 31034096; PMCID: PMC6609550.

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UUN 88367

UUN 88367

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