YMU1 is a human thymidylate kinase (hTMPK) inhibitor that lacks inhibitory effect on the activity of purified thymidine kinase 1 (TK1). YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Blocking hTMPK by YMU1 attenuates the ATP binding-induced closed conformation that is required for phosphorylation of dTMP and sensitizes cancer cells for low-dose doxorubicin chemotherapy.
MedKoo Cat#: 574941
Name: YMU1
CAS#: 902589-96-2
Chemical Formula: C17H22N4O4S
Exact Mass: 378.1362
Molecular Weight: 378.45
Elemental Analysis: C, 53.95; H, 5.86; N, 14.80; O, 16.91; S, 8.47
The following data is based on the product molecular weight 378.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
